Showing papers by "Mariana F. Fernández published in 2017"
TL;DR: It is suggested that historical exposure to HCB and β-HCH is consistently associated with the risk of metabolic disorders, and that these POPs might be partly responsible for the morbidity risk traditionally attributed to age and obesity.
56 citations
TL;DR: Adipose tissue samples in this study were found to contain environmental chemicals considered to be non‐persistent, whose levels were weakly or not at all correlated with the urine burden, therefore, adipose tissue may potentially provide additional information to that obtained from other biological matrices.
49 citations
TL;DR: This study lends support for an increase in preterm birth risk with atmospheric pressure with first-trimester average atmospheric pressure, and no evidence of adverse association with atmospheric pollutants was observed.
Abstract: Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994-2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the -5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure.
41 citations
TL;DR: A new analytical procedure based on ultrasound-assisted extraction (UAE) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) can provide information on foetal exposure to compounds, which has been little studied.
37 citations
TL;DR: This is the first report on the distribution of nine essential and possibly-essential TEs in adipose tissue and on their determinants in a human cohort and might serve as an initial step in the elucidation of their clinical relevance.
14 citations
TL;DR: Characterization of RF‐EMF exposure may be important to further investigate the mechanisms and underlying effects of electromagnetic fields (EMF) on infant health, and considering newborns vulnerability, it is wise to adopt a prudent avoidance strategy.
13 citations
TL;DR: The INMA project has contributed to provide increasing evidence of the association between prenatal exposure to persistent organic pollutants and child neuropsychological development, but it has also shown that postnatal exposure to these compounds does not play a role in this association.
11 citations
TL;DR: Cancer treatment may be responsible for the increase in TEXB-alpha observed in patients with hormone-dependent tumors, which may confer to xenoestrogens a role in the progression of the disease.
5 citations
Journal Article•
TL;DR: In this paper, a hipotesis clinica de disrupcion endocrina sugiere que exposicion humana a contaminantes ambientales-disruptores endocrinos (DE) con actividad como "obesogenos" interfiere de forma inapropiada sobre el metabolismo lipidico and the adipogenesis, entre otros mecanismos, promoviendo el sobrepeso and la obesidad.
Abstract: La prevalencia de sobrepeso y obesidad se ha incrementado de manera notable en las ultimas decadas, constituyendo un gran problema de salud publica. El desequilibrio del balance energetico, consecuencia de una alta ingesta calorica y un bajo gasto energetico, es incapaz de explicar por si solo este incremento, de manera que otros factores conductuales, geneticos y ambientales deben estar jugando un papel importante. La hipotesis clinica de disrupcion endocrina sugiere que la exposicion humana a contaminantes ambientales-disruptores endocrinos (DE) con actividad como “obesogenos”, interfiere de forma inapropiada sobre el metabolismo lipidico y la adipogenesis, entre otros mecanismos, promoviendo el sobrepeso y la obesidad. El catalogo completo de residuos quimicos que pueden contribuir a esta hipotesis ambiental no esta aun establecido, aunque ya se conocen algunos compuestos obesogenos. La identificacion de sustancias quimicas directamente relacionadas con el desarrollo de obesidad y sus complicaciones metabolicas contribuiria a establecer y mejorar las recomendaciones y exigencias de los estamentos publicos y privados para la seguridad alimentaria y de bienes de consumo y, en definitiva, las politicas en salud publica.
1 citations