V
Valérie Siroux
Researcher at University of Grenoble
Publications - 234
Citations - 9962
Valérie Siroux is an academic researcher from University of Grenoble. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 49, co-authored 203 publications receiving 8015 citations. Previous affiliations of Valérie Siroux include Joseph Fourier University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Relationships of active smoking to asthma and asthma severity in the EGEA study. Epidemiological study on the Genetics and Environment of Asthma.
TL;DR: It is concluded that active smoking is not a risk factor for asthma in adulthood, but that smoking increases asthma severity.
Journal ArticleDOI
Effect of 17q21 variants and smoking exposure in early-onset asthma.
Emmanuelle Bouzigon,Eve Corda,Hugues Aschard,Marie-Hélène Dizier,Anne Boland,Jean Bousquet,Nicolas Chateigner,Frédéric Gormand,Jocelyne Just,Nicole Le Moual,Pierre Scheinmann,Valérie Siroux,Daniel Vervloet,Diana Zelenika,Isabelle Pin,Francine Kauffmann,G. Mark Lathrop,Florence Demenais +17 more
TL;DR: This study shows that the increased risk of asthma conferred by 17q21 genetic variants is restricted to early-onset asthma and that the risk is further increased by early-life exposure to environmental tobacco smoke.
Journal ArticleDOI
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Florence Demenais,Patricia Margaritte-Jeannin,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmüller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Myriam Brossard,Guy Brusselle,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Thomas J. Hudson,Jennie Hui,Medea Imboden,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Alan James,Christer Janson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Rajesh Kumar,Ashok Kumar,Ashok Kumar,Ashok Kumar,Mikko Kuokkanen,Mikko Kuokkanen,Lies Lahousse,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Mads Melbye,Mads Melbye,Erik Melén,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Hamida Mohamdi,Arthur W. Musk,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Cameron D. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Amaury Vaysse,Sailaja Vedantam,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +216 more
TL;DR: A meta-analysis of GWAS studies for asthma from multiancestral cohorts identifies five new loci and finds that the asthma-associated loci are enriched near enhancer marks in immune cells, suggesting a major role of these loci in the regulation of immunologically related mechanisms.
Journal ArticleDOI
Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis
Martin Adam,Martin Adam,Tamara Schikowski,Anne-Elie Carsin,Yutong Cai,Bénédicte Jacquemin,Margaux Sanchez,Andrea Vierkötter,Alessandro Marcon,Dirk Keidel,Dirk Keidel,Dorothee Sugiri,Zaina Al Kanani,Rachel Nadif,Valérie Siroux,Rebecca Hardy,Diana Kuh,Thierry Rochat,Pierre-Olivier Bridevaux,Marloes Eeftens,Marloes Eeftens,Marloes Eeftens,Ming-Yi Tsai,Ming-Yi Tsai,Simona Villani,Harish C. Phuleria,Harish C. Phuleria,Matthias Birk,Josef Cyrys,Marta Cirach,Audrey de Nazelle,Mark J. Nieuwenhuijsen,Bertil Forsberg,Kees de Hoogh,Christophe Declerq,Roberto Bono,Pavilio Piccioni,Ulrich Quass,Joachim Heinrich,Deborah Jarvis,Deborah Jarvis,Isabelle Pin,Rob Beelen,Gerard Hoek,Bert Brunekreef,Christian Schindler,Christian Schindler,Jordi Sunyer,Ursula Krämer,Francine Kauffmann,Anna Hansell,Anna Hansell,Nino Künzli,Nino Künzli,Nicole Probst-Hensch,Nicole Probst-Hensch +55 more
TL;DR: It is observed that a 10 μg·m−3 increase in NO2 exposure was associated with lower levels of FEV1, and this study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Florence Demenais,Patricia Margaritte-Jeannin,Kathleen C. Barnes,William O.C.M. Cookson,Janine Altmueller,Wei Ang,R. Graham Barr,Terri H. Beaty,Allan B. Becker,John Beilby,Hans Bisgaard,Unnur S. Bjornsdottir,Eugene R. Bleecker,Klaus Bønnelykke,Dorret I. Boomsma,Emmanuelle Bouzigon,Christopher E. Brightling,Myriam Brossard,Guy Brusselle,Esteban G. Burchard,Kristin M. Burkart,Andrew Bush,Moira Chan-Yeung,Kian Fan Chung,Alexessander Couto Alves,John A. Curtin,Adnan Custovic,Denise Daley,Johan C. de Jongste,Blanca E. Del-Rio-Navarro,Kathleen M. Donohue,Liesbeth Duijts,Celeste Eng,Johan G. Eriksson,Martin Farrall,Yuliya Fedorova,Bjarke Feenstra,Manuel A. R. Ferreira,Maxim B. Freidin,Zofia K. Z. Gajdos,Jim Gauderman,Ulrike Gehring,Frank Geller,Jon Genuneit,Sina A. Gharib,Frank D. Gilliland,Raquel Granell,Penelope E. Graves,Daniel F. Gudbjartsson,Tari Haahtela,Susan R. Heckbert,Dick Heederik,Joachim Heinrich,Markku Heliövaara,John Henderson,Blanca E. Himes,Hiroshi Hirose,Joel N. Hirschhorn,Albert Hofman,Patrick G. Holt,Jouke J. Hottenga,Thomas J. Hudson,Jennie Hui,Medea Imboden,Vladimir P. Ivanov,Vincent W. V. Jaddoe,Alan James,Christer Janson,Marjo-Riitta Järvelin,Deborah Jarvis,Graham Jones,Ingileif Jonsdottir,Pekka Jousilahti,Michael Kabesch,Mika Kähönen,David B. Kantor,A. S. Karunas,Elza Khusnutdinova,Gerard H. Koppelman,Anita L. Kozyrskyj,Eskil Kreiner,Michiaki Kubo,Rajesh Kumar,Ashok Kumar,Mikko Kuokkanen,Lies Lahousse,Tarja Laitinen,Catherine Laprise,Mark Lathrop,Susanne Lau,Young-Ae Lee,Terho Lehtimäki,Sébastien Letort,Albert M. Levin,Guo Li,Liming Liang,Laura R. Loehr,Stephanie J. London,Daan W. Loth,Ani Manichaikul,Ingo Marenholz,Fernando J. Martinez,Melanie C. Matheson,Rasika A. Mathias,Kenji Matsumoto,Hamdi Mbarek,Wendy L. McArdle,Mads Melbye,Erik Melén,Deborah A. Meyers,Sven Michel,Hamida Mohamdi,Arthur W. Musk,Rachel A. Myers,Maartje A.E. Nieuwenhuis,Emiko Noguchi,George T. O'Connor,Ludmila M. Ogorodova,Cameron D. Palmer,Aarno Palotie,Julie E. Park,Craig E. Pennell,Göran Pershagen,Alexey Polonikov,Dirkje S. Postma,Nicole Probst-Hensch,V. P. Puzyrev,Benjamin A. Raby,Olli T. Raitakari,Adaikalavan Ramasamy,Stephen S. Rich,Colin F. Robertson,Isabelle Romieu,Muhammad T. Salam,Veikko Salomaa,Vivi Schlünssen,Robert A. Scott,P. A. Selivanova,Torben Sigsgaard,Angela Simpson,Valérie Siroux,Lewis J. Smith,Maria Solodilova,Marie Standl,Kari Stefansson,David P. Strachan,Bruno H. Stricker,Atsushi Takahashi,Philip J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Carla M. T. Tiesler,Dara G. Torgerson,Tatsuhiko Tsunoda,André G. Uitterlinden,Ralf J. P. van der Valk,Amaury Vaysse,Sailaja Vedantam,Andrea von Berg,Erika von Mutius,Judith M. Vonk,Johannes Waage,Nicholas J. Wareham,Scott T. Weiss,Wendy B. White,Magnus Wickman,Elisabeth Widen,Gonneke Willemsen,L. Keoki Williams,Inge M. Wouters,James J. Yang,Jing Hua Zhao,Miriam F. Moffatt,Carole Ober,Dan L. Nicolae +174 more