M
Marie Carlén
Researcher at Karolinska Institutet
Publications - 40
Citations - 8142
Marie Carlén is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Optogenetics & Neural stem cell. The author has an hindex of 23, co-authored 38 publications receiving 6920 citations. Previous affiliations of Marie Carlén include Picower Institute for Learning and Memory & McGovern Institute for Brain Research.
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Journal ArticleDOI
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Jessica A. Cardin,Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Ulf Knoblich,Feng Zhang,Karl Deisseroth,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Christopher I. Moore +11 more
TL;DR: The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
Journal ArticleDOI
Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
Konstantinos Meletis,Fanie Barnabé-Heider,Marie Carlén,Emma Evergren,Nikolay Tomilin,Oleg Shupliakov,Jonas Frisén +6 more
TL;DR: Using genetic fate mapping, it is shown that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal.
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Evidence for neurogenesis in the adult mammalian substantia nigra
Ming Zhao,Stefan Momma,Kioumars Delfani,Marie Carlén,Robert Cassidy,Clas B. Johansson,Hjalmar Brismar,Oleg Shupliakov,Jonas Frisén,Ann Marie Janson +9 more
TL;DR: Evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain is provided and it is shown that the rate of neurogenesis is increased after a lesion.
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A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Joshua H. Siegle,Jessica A. Cardin,Jessica A. Cardin,Kensuke Futai,D. Vierling-Claassen,D. Vierling-Claassen,C. Rühlmann,Stephanie R. Jones,Karl Deisseroth,Morgan Sheng,Christopher I. Moore,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +17 more
TL;DR: In this article, the authors show that mutant mice exhibit enhanced baseline cortical gamma rhythms, impaired gamma rhythm induction after optogenetic drive of parvalbumin (PV) interneurons and reduced sensitivity to the effects of NMDAR antagonists on gamma oscillations and stereotypies.
Journal ArticleDOI
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2
Jessica A. Cardin,Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Ulf Knoblich,Feng Zhang,Karl Deisseroth,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Christopher I. Moore +11 more
TL;DR: These optogenetic techniques provide a spatially and temporally precise means of studying neural activity in the intact brain and allow a detailed examination of the effect of evoked activity on the surrounding local neural network.