M
Marie-Cécile Michallet
Researcher at French Institute of Health and Medical Research
Publications - 74
Citations - 2556
Marie-Cécile Michallet is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transplantation & Bone marrow. The author has an hindex of 26, co-authored 67 publications receiving 2418 citations.
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Journal ArticleDOI
Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils
Anne-Laure Genestier,Marie-Cécile Michallet,Gilles Prévost,Gregory Bellot,Lara Chalabreysse,Simone Peyrol,Françoise Thivolet,Jerome Etienne,Gerard Lina,François M. Vallette,François Vandenesch,Laurent Genestier +11 more
TL;DR: Panton-Valentine leukocidin, which belongs to the pore-forming toxin family, could act at the mitochondrion level by creating pores in the mitochondrial outer membrane and was detected in lung sections of patients with necrotizing pneumonia, suggesting that PVL induces apoptosis in vivo and thereby is directly involved in the pathophysiology of necrotized pneumonia.
Journal ArticleDOI
Allogeneic bone marrow transplantation for acute myeloid leukemia in first remission: a randomized trial of a busulfan-Cytoxan versus Cytoxan-total body irradiation as preparative regimen: a report from the Group d'Etudes de la Greffe de Moelle Osseuse.
Didier Blaise,Dominique Maraninchi,Eric Archimbaud,Josy Reiffers,Agnès Devergie,Jean-Pierre Jouet,Noel-Jean Milpied,M. Attal,Marie-Cécile Michallet,Norbert Ifrah +9 more
TL;DR: The present limitation of busulfan use in this setting is demonstrated, possibly due to probable individual variations in biodisponibility, and besides the anti-leukemic effect of preparative regimens, the progress accomplished in BMT management is pointed out.
Journal ArticleDOI
Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation. BGMT Group
M. Attal,Didier Blaise,Gerald Marit,Catherine Payen,Marie-Cécile Michallet,Jean-Paul Vernant,C Sauvage,Xavier Troussard,Gerard Nedellec,Jose-Luis Pico +9 more
TL;DR: It is concluded that, in ALL, early allogeneic BMT after the BFM induction regimen is an effective consolidation treatment and that IL-2 does not decrease the high relapse rate observed after autologous BMT.
Journal ArticleDOI
Long-term outcome after allogeneic hematopoietic stem cell transplantation for advanced stage acute myeloblastic leukemia : a retrospective study of 379 patients reported to the Societe Francaise de Greffe de Moelle (SFGM)
Marie-Cécile Michallet,Xavier Thomas,J P Vernant,M Kuentz,Gérard Socié,H. Esperou-Bourdeau,Noel-Jean Milpied,Didier Blaise,Bernard Rio,Josy Reiffers,J P Jouet,J. Y. Cahn,J. H. Bourhis,Bruno Lioure,Michel Leporrier,Jean-Jacques Sotto,G Souillet,Laurent Sutton,Pierre Bordigoni,Francois Dreyfus,H. Tilly,N. Gratecos,M. Attal,P. Y. Leprise,François Demeocq,G. Michel,Agnès Buzyn,B Delmas-Marsalet,F. Bernaudin,Norbert Ifrah,A Sadoun,Denis Guyotat,M Cavazzana-Cavo,Denis Caillot,T de Revel,J P Vannier,André Baruchel,Nathalie Fegueux,M L Tanguy,Anne Thiebaut,A Belhabri,Eric Archimbaud +41 more
TL;DR: The results of this study suggest that the graft-versus-leukemia effect is important in advanced AML and that new HSCT modalities are needed for some patients with this indication.
Journal ArticleDOI
Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins.
Marie-Cécile Michallet,Xavier Préville,Monique Flacher,Sylvie Fournel,Laurent Genestier,Jean-Pierre Revillard +5 more
TL;DR: Results show that ATG may interfere with leukocyte responses to chemotactic signals but mostly inhibit the expression of integrins required for firm cellular adhesion, and may contribute to decreasing graft cellular infiltration during acute rejection and possibly after postischemic reperfusion.