M
Marie Charrel-Dennis
Researcher at University of Massachusetts Medical School
Publications - 5
Citations - 2595
Marie Charrel-Dennis is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Internalization & Phagocytosis. The author has an hindex of 4, co-authored 5 publications receiving 2306 citations. Previous affiliations of Marie Charrel-Dennis include Brigham and Women's Hospital & Harvard University.
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Journal ArticleDOI
AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC
Veit Hornung,Veit Hornung,Andrea Ablasser,Andrea Ablasser,Marie Charrel-Dennis,Franz Bauernfeind,Franz Bauernfeind,Gabor Horvath,Daniel R. Caffrey,Eicke Latz,Katherine A. Fitzgerald +10 more
TL;DR: Using mouse and human cells, the PYHIN (pyrin and HIN domain-containing protein) family member absent in melanoma 2 (AIM2) is identified as a receptor for cytosolic DNA, which regulates caspase-1.
Journal ArticleDOI
A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2
Qun Wang,Rachel M. McLoughlin,Brian A. Cobb,Brian A. Cobb,Marie Charrel-Dennis,Marie Charrel-Dennis,Kathleen J. Zaleski,Douglas T. Golenbock,Arthur O. Tzianabos,Dennis L. Kasper,Dennis L. Kasper +10 more
TL;DR: Toll-like receptors are identified as crucial to the convergence of innate and adaptive responses stimulated by PSA, which potentially modulate the Th1/Th2 cell balance and the response to infection by coordinating both the innate andadaptive pathways.
Journal ArticleDOI
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA
Marie Charrel-Dennis,Eicke Latz,Kristen A. Halmen,Patrick Trieu-Cuot,Katherine A. Fitzgerald,Dennis L. Kasper,Dennis L. Kasper,Douglas T. Golenbock +7 more
TL;DR: In this article, the authors found that IFN-β was produced by macrophages upon stimulation with both heat-killed and live group B streptococcus (GBS) DNA.
Journal ArticleDOI
Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling
Vishal Jain,Annett Halle,Kristen A. Halmen,Egil Lien,Marie Charrel-Dennis,Sanjay Ram,Douglas T. Golenbock,Alberto Visintin +7 more
TL;DR: The data confirm the notion that soluble MD-2 is a genuine opsonin that enhances proinflammatory opsonophagocytosis by bridging live gram-negative bacteria to the LPS transducing complex and extend the understanding of the role of the TLR4/MD-2 signaling axis in bacterial recognition by phagocytes.
bacteria depend on TLR4 signaling Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative
Alberto Visintin,Vishal Jain,Annett Halle,Kristen A. Halmen,Egil Lien,Marie Charrel-Dennis,Sanjay Ram +6 more
TL;DR: The data confirms the notion that soluble MD-2 is a genuine opsonin which enhances pro-inflammatory opsonophagocytosis by bridging live Gram-negative bacteria to the LPS transducing complex and extends the understanding of the role of the TLR4/MD-2 signaling axis in bacterial recognition by phagocytes.