M
Marie-Christine Many
Researcher at Université catholique de Louvain
Publications - 80
Citations - 4221
Marie-Christine Many is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Thyroid & Thyroid peroxidase. The author has an hindex of 34, co-authored 79 publications receiving 3960 citations. Previous affiliations of Marie-Christine Many include Catholic University of Leuven & Free University of Brussels.
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Journal ArticleDOI
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
Xavier De Deken,Dantong Wang,Marie-Christine Many,Sabine Costagliola,Frédérick Libert,Gilbert Vassart,Jacques Emile Dumont,Françoise Miot +7 more
TL;DR: Two cDNAs encoding NADPH oxidases and constituting the thyroid H2O2 generating system have been cloned and the dog mRNA expression is thyroid-specific and up-regulated by agents activating the cAMP pathway as is the synthesis of the polypeptides they are coding for.
Journal Article
Genetic Immunization Against the Human Thyrotropin Receptor Causes Thyroiditis and Allows Production of Monoclonal Antibodies Recognizing the Native Receptor
TL;DR: It is reported that a humoral response against the native hTSHR, compatible with mAb production, is elicited in mice by immunization with a DNA construct encoding the receptor.
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Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
Sabine Costagliola,Valérie Panneels,Marco Bonomi,Jana Koch,Marie-Christine Many,Guillaume Smits,Gilbert Vassart +6 more
TL;DR: Site‐directed mutagenesis experiments indicate that the motif, which is conserved in all members of the glycoprotein hormone receptor family, seems to play a similar role in the LH/CG and FSH receptors.
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Roles of hydrogen peroxide in thyroid physiology and disease
Yue Song,Natacha Driessens,Marco Costa,X De Deken,Vincent Detours,Bernard Corvilain,Carine Maenhaut,Françoise Miot,J. Van Sande,Marie-Christine Many,Jacques Emile Dumont +10 more
TL;DR: It is proposed that various pathologies can be explained, at least in part, by overproduction and lack of degradation of H2O2 (tumorigenesis, myxedematous cretinism, and thyroiditis) and by failure of the H 2O2 generation or its positive control system (congenital hypothyroidism).
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Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves’ disease
Sabine Costagliola,Marie-Christine Many,Jean-François Denef,Joachim Pohlenz,Samuel Refetoff,Gilbert Vassart +5 more
TL;DR: The results demonstrate that genetic immunization of outbred NMRI mice with the human TSHr provides the most convincing murine model of Graves' disease available to date.