G
Gilbert Vassart
Researcher at Université libre de Bruxelles
Publications - 461
Citations - 43002
Gilbert Vassart is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Receptor & Thyroglobulin. The author has an hindex of 101, co-authored 458 publications receiving 41430 citations. Previous affiliations of Gilbert Vassart include Free University of Brussels & University of Pisa.
Papers
More filters
Journal ArticleDOI
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
Michel Samson,Frédérick Libert,Benjamin J. Doranz,Joseph Rucker,Corinne Liesnard,Claire-Michèle Farber,Sentob Saragosti,Claudine Lapoumeroulie,Jacqueline Cognaux,Christine Forceille,Gaëtan Muyldermans,Chris Verhofstede,Guy Burtonboy,Michel Georges,Tsuneo Imai,Shalini Rana,Yanji Yi,Robert J. Smyth,Ronald G. Collman,Robert W. Doms,Gilbert Vassart,Marc Parmentier +21 more
TL;DR: It is shown that a mutant allele of CCR-5 is present at a high frequency in caucasian populations, but is absent in black populations from Western and Central Africa and Japanese populations, and a 32-base-pair deletion within the coding region results in a frame shift, and generates a non-functional receptor that does not support membrane fusion or infection by macrophage- and dual-tropic HIV-1 strains.
Journal ArticleDOI
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Jean-Claude Meunier,Catherine Mollereau,Lawrence Toll,Lawrence Toll,Charles Suaudeau,Christiane Moisand,Paul Alvinerie,Jean-Luc Butour,Jean-Claude Guillemot,Pascual Ferrara,Bernard Monsarrat,Honoré Mazarguil,Gilbert Vassart,Marc Parmentier,Jean Costentin +14 more
TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal ArticleDOI
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice
Catherine Ledent,Olga Valverde,G Cossu,François Petitet,Jean-François Aubert,Françoise Beslot,Georg Andrees Bohme,Assunta Imperato,Thierry Pedrazzini,Bernard P. Roques,Gilbert Vassart,Walter Fratta,Marc Parmentier +12 more
TL;DR: Observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.
Journal ArticleDOI
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul,Cecile Loison,Sofie Struyf,Jean-Yves Springael,Vincent Lannoy,Marie-Eve Decobecq,Stéphane Brézillon,Vincent Dupriez,Gilbert Vassart,Jozef Van Damme,Marc Parmentier,Michel Detheux +11 more
TL;DR: The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.