M
Marie-Eve Brien
Researcher at Université de Montréal
Publications - 17
Citations - 441
Marie-Eve Brien is an academic researcher from Université de Montréal. The author has contributed to research in topics: Pregnancy & Medicine. The author has an hindex of 7, co-authored 9 publications receiving 309 citations.
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Journal ArticleDOI
Sterile inflammation and pregnancy complications: a review.
Mathieu Nadeau-Vallée,Dima Obari,Julia Palacios,Marie-Eve Brien,Cyntia Duval,Sylvain Chemtob,Sylvie Girard +6 more
TL;DR: The role of sterile inflammation in reproduction, including early implantation and pregnancy complications is discussed, and major alarmins vastly implicated in numerous sterile inflammatory processes, such as uric acid, HMGB1, IL-1α and cell-free DNA are focused on while giving an overview of the potential role of other candidate alarmins.
Journal ArticleDOI
Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice
Mathieu Nadeau-Vallée,Peck-Yin Chin,Lydia Belarbi,Marie-Eve Brien,Sheetal Pundir,Martin H. Berryer,Alexandra Beaudry-Richard,Ankush Madaan,David J. Sharkey,Alexis Lupien-Meilleur,Xin Hou,Christiane Quiniou,Alexandre Beaulac,Ines Boufaied,Amarilys Boudreault,Adriana Carbonaro,Ngoc-Duc Doan,Jean-Sébastien Joyal,William D. Lubell,David M. Olson,Sarah A. Robertson,Sylvie Girard,Sylvain Chemtob +22 more
TL;DR: The results implicate IL-1 as an important driver of neonatal morbidity in PTB and identify 101.10 as a safe and effective candidate therapeutic.
Journal ArticleDOI
Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1–Dependent Pathway: Implications for Fetal Growth Restriction
Marie-Eve Brien,Cyntia Duval,Julia Palacios,Ines Boufaied,Andrée-Anne Hudon-Thibeault,Mathieu Nadeau-Vallée,Cathy Vaillancourt,Colin P. Sibley,Colin P. Sibley,Vikki M. Abrahams,Rebecca Jones,Rebecca Jones,Sylvie Girard +12 more
TL;DR: A novel in vivo animal model of noninfectious inflammation during pregnancy is described, which is triggered by MSU crystals and leads to reduced fetal growth.
Journal ArticleDOI
Alarmins at the maternal-fetal interface: involvement of inflammation in placental dysfunction and pregnancy complications 1.
Marie-Eve Brien,Bernadette Baker,Bernadette Baker,Cyntia Duval,Virginie Gaudreault,Rebecca Jones,Rebecca Jones,Sylvie Girard +7 more
TL;DR: The current state of knowledge about the role of DAMPs in pregnancy complications including preeclampsia, fetal growth restriction, preterm birth, and stillbirth and possible therapeutic strategies to preserve placental function is covered.
Journal ArticleDOI
Distinct inflammatory profile in preeclampsia and postpartum preeclampsia reveal unique mechanisms.
TL;DR: This work reveals changes within the maternal immune system in both PE and PPPE, and indicates a striking contrast in how this occurs, and suggests a prenatal initiation of the postpartum pathology.