M
Marie-Hélène Metz-Boutigue
Researcher at French Institute of Health and Medical Research
Publications - 122
Citations - 5075
Marie-Hélène Metz-Boutigue is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Chromogranin A & Antimicrobial peptides. The author has an hindex of 39, co-authored 118 publications receiving 4739 citations. Previous affiliations of Marie-Hélène Metz-Boutigue include University of Strasbourg & Centre national de la recherche scientifique.
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Journal ArticleDOI
Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins
Marie-Hélène Metz-Boutigue,Jacqueline Jolles,Joël Mazurier,FranGoise Schoentgen,Dorninique Legrand,Geneviève Spik,Jean Montreuil,Pierre Jolles +7 more
TL;DR: The complete amino acid sequence (703 amino acid residues) of human lactotransferrin has been determined and prediction of the secondary structure of the two homologous moieties of human dairy product has been performed.
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The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties.
TL;DR: Endocrine regulations are indicated from in vivo studies, consistent with the postulated prohormone function of CgA for peptides with regulatory properties, implicating C gA peptides in regulation of calcium and glucose metabolism, cardiovascular functions, gastrointestinal motility and nociception, tissue repair, inflammatory responses and in the first phase of microbial invasions.
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Intracellular and extracellular processing of chromogranin A: Determination of cleavage sites
TL;DR: The structural features of the proteolytic degradation mechanism have been characterized with regard to the possible function of CGA as a prohormone, as suggested by recent studies.
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Self-Defensive Biomaterial Coating Against Bacteria and Yeasts: Polysaccharide Multilayer Film with Embedded Antimicrobial Peptide
G. Cado,R. Aslam,Lydie Séon,Tony Garnier,Roxane Fabre,Audrey Parat,Armelle Chassepot,Jean-Claude Voegel,Bernard Senger,Francis Schneider,Y. Frère,Loïc Jierry,Loïc Jierry,Pierre Schaaf,Halima Kerdjoudj,Marie-Hélène Metz-Boutigue,Fouzia Boulmedais +16 more
TL;DR: The first self‐defensive coating against both bacteria and yeasts is reported, where the release of the antimicrobial peptide is triggered by enzymatic degradation of the film due to the pathogens themselves.
Journal ArticleDOI
Antibacterial and Antifungal Activities of Vasostatin-1, the N-terminal Fragment of Chromogranin A
Karine Lugardon,Roselyne Raffner,Yannick Goumon,Angelo Corti,Agnès F. Delmas,Philippe Bulet,Dominique Aunis,Marie-Hélène Metz-Boutigue +7 more
TL;DR: Vasostatin-1, which is stored in a large variety of cells and which is liberated from stimulated chromaffin and immune cells upon stress, may represent a new component active in innate immunity.