Marike Lancel

TL;DR: The physiological role of the HCN2 subunit is defined as a major determinant of membrane resting potential that is required for regular cardiac and neuronal rhythmicity.

TL;DR: An overview of existing literature on the relation between poor sleep and aggression, irritability, and hostility is given and individual variation within these neurobiological systems may be responsible for amplified aggressive responses induced by sleep loss in certain individuals.

TL;DR: In both rats and normal sleeping individuals, agonistic modulators are able to reduce sleep latency, increase sleep continuity, and promote non-rapid-eye-movement (NREM) sleep as well as the occurrence of spindles, which implies that an activation of GABAA receptors plays a crucial role in the initiation and maintenance of NREM sleep and in the generation of sleep spindle activity.

TL;DR: The effects of progesterone on sleep closely resemble those of agonistic modulators of GABAA receptors such as benzodiazepines and correlate well with the increases in the levels of its GAB AA agonistic metabolites.

TL;DR: It is demonstrated that 3alpha-reduced neuroactive steroids concurrently modulate the GABA(A) receptor and regulate gene expression via the progesterone receptor after intracellular oxidation, and first studies in patients with panic disorder suggest that neuro active steroids may also play a pivotal role in human anxiety.