M
Mario Chiariello
Researcher at National Institutes of Health
Publications - 82
Citations - 12096
Mario Chiariello is an academic researcher from National Institutes of Health. The author has contributed to research in topics: G protein-coupled receptor & MAP kinase kinase kinase. The author has an hindex of 33, co-authored 73 publications receiving 10441 citations. Previous affiliations of Mario Chiariello include National Research Council & University of Naples Federico II.
Papers
More filters
Journal ArticleDOI
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.
Anna Lucia Fallacara,Arianna Mancini,Arianna Mancini,Claudio Zamperini,Elena Dreassi,Stefano Marianelli,Mario Chiariello,Gianni Pozzi,Francesco Santoro,Maurizio Botta,Maurizio Botta,Silvia Schenone +11 more
TL;DR: Optimizing a desolvation method-based procedure for preparing HSA nanoparticles increases the solubility of pyrazolo[3,4-d]pyrimidine avoiding the use of DMSO as solubilizing agent and creates a profitable balance of stability, small size and a similar activity compared to the free drugs in cell-based assays.
Journal ArticleDOI
Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity
TL;DR: It is indicated that inhibition of HDAC activity antagonizes the mitogenic effect of PDGF, suggesting that these drugs may specifically act on the expression of STAT-dependent, PDGF-responsive genes.
Journal ArticleDOI
Quinone-Fused Pyrazoles through 1,3-Dipolar Cycloadditions: Synthesis of Tricyclic Scaffolds and in vitro Cytotoxic Activity Evaluation on Glioblastoma Cancer Cells.
Giulio Bertuzzi,Simone Crotti,Pierpaolo Calandro,Bianca F. Bonini,Ilaria Monaco,Erica Locatelli,Mariafrancesca Fochi,Paolo Zani,Elena Strocchi,Andrea Mazzanti,Mario Chiariello,Mauro Comes Franchini +11 more
TL;DR: In vitro studies confirmed the potent anticancer effects of the novel and straightforward synthesis of highly substituted isoquinoline‐5,8‐dione fused tricyclic pyrazoles, showing promising IC50 values as low as 2.5 μm against three different glioblastoma cell lines.
Journal ArticleDOI
MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process
TL;DR: It is demonstrated that MAPK15 stimulated 5′-AMP–activated protein kinase–dependent activity of UNC-51-like kinase 1 (ULK1), the onlyprotein kinase among the ATG-related proteins, toward downstream substrates and signaling intermediates and mediated ULK1 activation induced by starvation, a classical stimulus for the autophagic process.
Journal ArticleDOI
Surface modification of nanocellulose through carbamate link for a selective release of chemotherapeutics
Silvia Tortorella,Mirko Maturi,Francesca Dapporto,Chiara Spanu,Letizia Sambri,Mauro Comes Franchini,Mario Chiariello,Erica Locatelli +7 more
TL;DR: The synthesis of cellulose nanocrystals covalently bound to a model chemotherapeutic drug (DOXO) via a novel spacer arm, which acts both as linker and as selective releasing agent, shows stability in aqueous environments for a wide range of conditions.