Showing papers by "Mario L. Suvà published in 2013"
TL;DR: In this article, the authors review conceptual parallels between the respective biological phenomena, highlighting important interrelationships among transcription factors, chromatin regulators, and preexisting epigenetic states, and provide insights into oncogenic transformation, tumor heterogeneity, and cancer stem cell models.
Abstract: The demonstration of induced pluripotency and direct lineage conversion has led to remarkable insights regarding the roles of transcription factors and chromatin regulators in mediating cell state transitions. Beyond its considerable implications for regenerative medicine, this body of work is highly relevant to multiple stages of oncogenesis, from the initial cellular transformation to the hierarchical organization of established malignancies. Here, we review conceptual parallels between the respective biological phenomena, highlighting important interrelationships among transcription factors, chromatin regulators, and preexisting epigenetic states. The shared mechanisms provide insights into oncogenic transformation, tumor heterogeneity, and cancer stem cell models.
637 citations
TL;DR: A comparative analysis of chromatin state in GBM CSCs is presented that reveals widespread activation of genes normally held in check by Polycomb repressors, and demonstrates regulatory connections among ASCL1, Wnt signaling, and collaborating TFs that are essential for the maintenance and tumorigenicity of GBMCSCs.
249 citations
TL;DR: Recent studies begin to provide an in-depth view of the molecular routes leading to brain tumour development, which will be critical for refining classification systems and improving clinical management.
Abstract: Purpose of reviewSystematic use of next-generation sequencing technologies has transformed the field of cancer genomics, leading to the identification of genetic alterations in an unanticipated number of genes and regulatory elements. Here, we review recent advances in brain tumour genomics and high
17 citations