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Anoop P. Patel
Researcher at University of Washington
Publications - 49
Citations - 12557
Anoop P. Patel is an academic researcher from University of Washington. The author has contributed to research in topics: Neocortex & Biology. The author has an hindex of 20, co-authored 42 publications receiving 8795 citations. Previous affiliations of Anoop P. Patel include University of Medicine and Dentistry of New Jersey & Howard Hughes Medical Institute.
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Journal ArticleDOI
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Anoop P. Patel,Itay Tirosh,John J. Trombetta,Alex K. Shalek,Shawn M. Gillespie,Hiroaki Wakimoto,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,David N. Louis,Orit Rozenblatt-Rosen,Mario L. Suvà,Mario L. Suvà,Aviv Regev,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +19 more
TL;DR: The genome sequence of single cells isolated from brain glioblastomas was examined, which revealed shared chromosomal changes but also extensive transcription variation, including genes related to signaling, which represent potential therapeutic targets.
Journal ArticleDOI
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
Sidharth V. Puram,Itay Tirosh,Itay Tirosh,Anuraag S. Parikh,Anoop P. Patel,Keren Yizhak,Shawn M. Gillespie,Shawn M. Gillespie,Christopher Rodman,Christina L. Luo,Edmund A. Mroz,Kevin S. Emerick,Daniel G. Deschler,Daniel G. Deschler,Mark A. Varvares,Mark A. Varvares,Ravi Mylvaganam,Orit Rozenblatt-Rosen,James W. Rocco,James W. Rocco,James W. Rocco,William C. Faquin,Derrick T. Lin,Derrick T. Lin,Aviv Regev,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein +28 more
TL;DR: In this article, the authors profiled transcriptomes of ∼6,000 single cells from 18 head and neck squamous cell carcinoma (HNSCC) patients, including five matched pairs of primary tumors and lymph node metastases.
Journal ArticleDOI
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel,Julie Laffy,Mariella G. Filbin,Toshiro Hara,Marni E. Shore,Marni E. Shore,Gilbert J. Rahme,Gilbert J. Rahme,Alyssa R. Richman,Alyssa R. Richman,Dana Silverbush,Dana Silverbush,McKenzie Shaw,Christine M. Hebert,Christine M. Hebert,John M. DeWitt,John M. DeWitt,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Elizabeth M. Perez,L. Nicolas Gonzalez Castro,Xiaoyang Lan,Xiaoyang Lan,Nicholas Druck,Christopher Rodman,Danielle Dionne,Alexander Kaplan,Mia Bertalan,Julia L. Small,Kristine Pelton,Sarah Becker,Dennis M. Bonal,Quang-Dé Nguyen,Rachel L. Servis,Jeremy M. Fung,Ravindra Mylvaganam,Lisa Mayr,Johannes Gojo,Christine Haberler,René Geyeregger,Thomas Czech,Irene Slavc,Brian V. Nahed,William T. Curry,Bob S. Carter,Hiroaki Wakimoto,Priscilla K. Brastianos,Tracy T. Batchelor,Anat Stemmer-Rachamimov,Maria Martinez-Lage,Matthew P. Frosch,Ivan Stamenkovic,Nicolo Riggi,Esther Rheinbay,Esther Rheinbay,Michelle Monje,Orit Rozenblatt-Rosen,Daniel P. Cahill,Anoop P. Patel,Tony Hunter,Inder M. Verma,Keith L. Ligon,Keith L. Ligon,David N. Louis,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Itay Tirosh,Mario L. Suvà,Mario L. Suvà +71 more
TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.
Journal ArticleDOI
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
Itay Tirosh,Andrew S. Venteicher,Andrew S. Venteicher,Christine Hebert,Christine Hebert,Leah E. Escalante,Leah E. Escalante,Anoop P. Patel,Keren Yizhak,Keren Yizhak,Jonathan M. Fisher,Christopher Rodman,Christopher Mount,Mariella G. Filbin,Mariella G. Filbin,Cyril Neftel,Cyril Neftel,Niyati Desai,Jackson Nyman,Benjamin Izar,Christina C. Luo,Joshua M. Francis,Joshua M. Francis,Aanand A. Patel,Maristela L. Onozato,Nicolo Riggi,Kenneth J. Livak,David Gennert,Rahul Satija,Brian V. Nahed,William T. Curry,Robert L. Martuza,Ravindra Mylvaganam,A. John Iafrate,Matthew P. Frosch,Todd R. Golub,Todd R. Golub,Todd R. Golub,Miguel Rivera,Miguel Rivera,Gad Getz,Gad Getz,Orit Rozenblatt-Rosen,Daniel P. Cahill,Michelle Monje,Bradley E. Bernstein,Bradley E. Bernstein,David N. Louis,Aviv Regev,Aviv Regev,Mario L. Suvà,Mario L. Suvà +51 more
TL;DR: In this paper, the authors profile 4,347 single cells from six IDH1 or IDH2 mutant human oligodendrogliomas by RNA sequencing and reconstruct their developmental programs from genome-wide expression signatures.
Journal ArticleDOI
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suvà,Mario L. Suvà,Mario L. Suvà,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Anoop P. Patel,Anoop P. Patel,Hiroaki Wakimoto,Samuel D. Rabkin,Nicolo Riggi,Nicolo Riggi,Anthony Wei Shine Chi,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,Miguel Rivera,Miguel Rivera,Nikki E. Rossetti,Nikki E. Rossetti,Simon Kasif,Samantha Beik,Sabah Kadri,Itay Tirosh,Ivo Wortman,Alex K. Shalek,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev,David N. Louis,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +37 more
TL;DR: In this paper, a core set of neurodevelopmental transcription factors (POU3F2, SOX2, SALL2, and OLIG2) are identified as essential for GBM propagation.