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Esther Rheinbay
Researcher at Harvard University
Publications - 49
Citations - 9701
Esther Rheinbay is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 19, co-authored 32 publications receiving 7543 citations. Previous affiliations of Esther Rheinbay include Broad Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
Daniel J. Brat,Roel G.W. Verhaak,Kenneth Aldape,W. K. Alfred Yung,Sofie R. Salama,Lee Cooper,Esther Rheinbay,C. Ryan Miller,Mark Vitucci,Olena Morozova,A. Gordon Robertson,Houtan Noushmehr,Peter W. Laird,Andrew D. Cherniack,Rehan Akbani,Jason T. Huse,Giovanni Ciriello,Laila M. Poisson,Jill S. Barnholtz-Sloan,Mitchel S. Berger,Cameron Brennan,Rivka R. Colen,Howard Colman,Adam E. Flanders,Caterina Giannini,Mia Grifford,Antonio Iavarone,Rajan Jain,Isaac Joseph,Jaegil Kim,Katayoon Kasaian,Tom Mikkelsen,Bradley A. Murray,Brian P. O'Neill,Lior Pachter,Donald W. Parsons,Carrie Sougnez,Erik P. Sulman,Scott R. VandenBerg,Erwin G. Van Meir,Andreas von Deimling,Hailei Zhang,Daniel Crain,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Troy Shelton,Mark E. Sherman,Peggy Yena,Aaron D. Black,Jay Bowen,Katie Dicostanzo,Julie M. Gastier-Foster,Kristen M. Leraas,Tara M. Lichtenberg,Christopher R. Pierson,Nilsa C. Ramirez,Cynthia Taylor,Stephanie Weaver,Lisa Wise,Erik Zmuda,Tanja M. Davidsen,John A. Demchok,Greg Eley,Martin L. Ferguson,Carolyn M. Hutter,Kenna R. Mills Shaw,Bradley A. Ozenberger,Margi Sheth,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Brenda Ayala,Julien Baboud,Sudha Chudamani,Mark A. Jensen,Jia Liu,Todd Pihl,Rohini Raman,Yunhu Wan,Ye Wu,Adrian Ally,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Stephen B. Baylin,Rameen Beroukhim,Moiz S. Bootwalla,Reanne Bowlby,Christopher A. Bristow,Denise Brooks,Yaron S.N. Butterfield,Rebecca Carlsen,Scott L. Carter,Lynda Chin,Andy Chu,Eric Chuah,Kristian Cibulskis,Amanda Clarke,Simon G. Coetzee,Noreen Dhalla,Timothy R. Fennell,Sheila A. Fisher,Stacey Gabriel,Gad Getz,Richard A. Gibbs,Ranabir Guin,Angela Hadjipanayis,D. Neil Hayes,Toshinori Hinoue,Katherine A. Hoadley,Robert A. Holt,Alan P. Hoyle,Stuart R. Jefferys,Steven J.M. Jones,Corbin D. Jones,Raju Kucherlapati,Phillip H. Lai,Eric S. Lander,Semin Lee,Lee Lichtenstein,Yussanne Ma,Dennis T. Maglinte,Harshad S. Mahadeshwar,Marco A. Marra,Michael Mayo,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,Richard A. Moore,Lisle E. Mose,Andrew J. Mungall,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Joel S. Parker,Charles M. Perou,Alexei Protopopov,Xiaojia Ren,Jeffrey Roach,Thais S. Sabedot,Jacqueline E. Schein,Steven E. Schumacher,Jonathan G. Seidman,Sahil Seth,Hui Shen,Janae V. Simons,Payal Sipahimalani,Matthew G. Soloway,Xingzhi Song,Huandong Sun,Barbara Tabak,Angela Tam,Donghui Tan,Jiabin Tang,Nina Thiessen,Timothy J. Triche,David Van Den Berg,Umadevi Veluvolu,Scot Waring,Daniel J. Weisenberger,Matthew D. Wilkerson,Tina Wong,Junyuan Wu,Liu Xi,Andrew Wei Xu,Lixing Yang,Travis I. Zack,Jianhua Zhang,B. Arman Aksoy,Harindra Arachchi,Chris Benz,Brady Bernard,Daniel E. Carlin,Juok Cho,Daniel DiCara,Scott Frazer,Gregory N. Fuller,Jianjiong Gao,Nils Gehlenborg,David Haussler,David I. Heiman,Lisa Iype,Anders Jacobsen,Zhenlin Ju,Sol Katzman,Hoon Kim,Theo A. Knijnenburg,Richard Kreisberg,Michael S. Lawrence,William M. Lee,Kalle Leinonen,Pei Lin,Shiyun Ling,Wen-Bin Liu,Yingchun Liu,Yuexin Liu,Yiling Lu,Gordon B. Mills,Sam Ng,Michael S. Noble,Evan O. Paull,Arvind Rao,Sheila Reynolds,Gordon Saksena,Zack Sanborn,Chris Sander,Nikolaus Schultz,Yasin Senbabaoglu,Ronglai Shen,Ilya Shmulevich,Rileen Sinha,Josh Stuart,S. Onur Sumer,Yichao Sun,Natalie Tasman,Barry S. Taylor,Doug Voet,Nils Weinhold,John N. Weinstein,Da Yang,Kosuke Yoshihara,Siyuan Zheng,Wei Zhang,Lihua Zou,Ty Abel,Sara Sadeghi,Mark L. Cohen,Jenny Eschbacher,Eyas M. Hattab,Aditya Raghunathan,Matthew Schniederjan,Dina Aziz,Gene Barnett,Wendi Barrett,Darell D. Bigner,Lori Boice,Cathy Brewer,Chiara Calatozzolo,Benito Campos,Carlos Gilberto Carlotti,Timothy A. Chan,Lucia Cuppini,Erin Curley,Stefania Cuzzubbo,Karen Devine,Francesco DiMeco,Rebecca Duell,J. Bradley Elder,Ashley Fehrenbach,Gaetano Finocchiaro,William A. Friedman,Jordonna Fulop,Johanna Gardner,Beth Hermes,Christel Herold-Mende,Christine Jungk,Ady Kendler,Norman L. Lehman,Eric S. Lipp,Ouida Liu,Randy Mandt,Mary McGraw,Roger E. McLendon,Christopher M. McPherson,Luciano Neder,Phuong L. Nguyen,Ardene Noss,Raffaele Nunziata,Quinn T. Ostrom,Cheryl A. Palmer,Alessandro Perin,Bianca Pollo,Alexander Potapov,Olga Potapova,W. Kimryn Rathmell,D L Rotin,Lisa Scarpace,Cathy Schilero,Kelly Senecal,Kristen Shimmel,Vsevolod Shurkhay,Suzanne Sifri,Rosy Singh,Andrew E. Sloan,Kathy Smolenski,Susan M. Staugaitis,Ruth Steele,Leigh B. Thorne,Daniela Pretti da Cunha Tirapelli,Andreas Unterberg,Mahitha Vallurupalli,Yun Wang,Ronald E. Warnick,Felicia Williams,Yingli Wolinsky,Sue E. Bell,Mara Rosenberg,Chip Stewart,Franklin W. Huang,Jonna Grimsby,Amie Radenbaugh,Jianan Zhang +306 more
TL;DR: The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class.
Journal ArticleDOI
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel,Julie Laffy,Mariella G. Filbin,Toshiro Hara,Marni E. Shore,Marni E. Shore,Gilbert J. Rahme,Gilbert J. Rahme,Alyssa R. Richman,Alyssa R. Richman,Dana Silverbush,Dana Silverbush,McKenzie Shaw,Christine M. Hebert,Christine M. Hebert,John M. DeWitt,John M. DeWitt,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Elizabeth M. Perez,L. Nicolas Gonzalez Castro,Xiaoyang Lan,Xiaoyang Lan,Nicholas Druck,Christopher Rodman,Danielle Dionne,Alexander Kaplan,Mia Bertalan,Julia L. Small,Kristine Pelton,Sarah Becker,Dennis M. Bonal,Quang-Dé Nguyen,Rachel L. Servis,Jeremy M. Fung,Ravindra Mylvaganam,Lisa Mayr,Johannes Gojo,Christine Haberler,René Geyeregger,Thomas Czech,Irene Slavc,Brian V. Nahed,William T. Curry,Bob S. Carter,Hiroaki Wakimoto,Priscilla K. Brastianos,Tracy T. Batchelor,Anat Stemmer-Rachamimov,Maria Martinez-Lage,Matthew P. Frosch,Ivan Stamenkovic,Nicolo Riggi,Esther Rheinbay,Esther Rheinbay,Michelle Monje,Orit Rozenblatt-Rosen,Daniel P. Cahill,Anoop P. Patel,Tony Hunter,Inder M. Verma,Keith L. Ligon,Keith L. Ligon,David N. Louis,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Itay Tirosh,Mario L. Suvà,Mario L. Suvà +71 more
TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.
Journal ArticleDOI
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains
Manching Ku,Richard Koche,Richard Koche,Richard Koche,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Eric M. Mendenhall,Eric M. Mendenhall,Mitsuhiro Endoh,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Aviva Presser,Aviva Presser,Chad Nusbaum,Xiaohui Xie,Andrew S. Chi,Andrew S. Chi,Mazhar Adli,Mazhar Adli,Simon Kasif,Leon M. Ptaszek,Chad A. Cowan,Eric S. Lander,Eric S. Lander,Haruhiko Koseki,Bradley E. Bernstein +26 more
TL;DR: It is proposed that large CpG islands depleted of activating motifs confer epigenetic memory by recruiting the full repertoire of Polycomb complexes in pluripotent cells.
Journal ArticleDOI
Evolution of pathogenicity and sexual reproduction in eight Candida genomes.
Geraldine Butler,Matthew D. Rasmussen,Michael F. Lin,Michael F. Lin,Manuel A. S. Santos,Sharadha Sakthikumar,Carol A. Munro,Esther Rheinbay,Esther Rheinbay,Manfred Grabherr,Anja Forche,Jennifer L. Reedy,Ino Agrafioti,Martha B. Arnaud,Steven Bates,Alistair J. P. Brown,Sascha Brunke,Maria C. Costanzo,David A. Fitzpatrick,Piet W. J. de Groot,David Harris,Lois L. Hoyer,Bernhard Hube,Frans M. Klis,Chinnappa D. Kodira,Nicola Lennard,Mary E. Logue,Ronny Martin,Aaron M. Neiman,Elissavet Nikolaou,Michael A. Quail,Janet Quinn,Maria C. Santos,Florian F. Schmitzberger,Gavin Sherlock,Prachi Shah,Kevin A. T. Silverstein,Marek S. Skrzypek,David R. Soll,Rodney Staggs,Ian Stansfield,Michael P. H. Stumpf,Peter E. Sudbery,Thyagarajan Srikantha,Qiandong Zeng,Judith Berman,Matthew Berriman,Joseph Heitman,Neil A. R. Gow,Michael C. Lorenz,Bruce W. Birren,Manolis Kellis,Manolis Kellis,Christina A. Cuomo +53 more
TL;DR: There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence in Candida albicans species.
Journal ArticleDOI
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Mario L. Suvà,Mario L. Suvà,Mario L. Suvà,Esther Rheinbay,Esther Rheinbay,Esther Rheinbay,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Anoop P. Patel,Anoop P. Patel,Hiroaki Wakimoto,Samuel D. Rabkin,Nicolo Riggi,Nicolo Riggi,Anthony Wei Shine Chi,Daniel P. Cahill,Brian V. Nahed,William T. Curry,Robert L. Martuza,Miguel Rivera,Miguel Rivera,Nikki E. Rossetti,Nikki E. Rossetti,Simon Kasif,Samantha Beik,Sabah Kadri,Itay Tirosh,Ivo Wortman,Alex K. Shalek,Orit Rozenblatt-Rosen,Aviv Regev,Aviv Regev,Aviv Regev,David N. Louis,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +37 more
TL;DR: In this paper, a core set of neurodevelopmental transcription factors (POU3F2, SOX2, SALL2, and OLIG2) are identified as essential for GBM propagation.