Mario Öeren

TL;DR: 3-Chlorooxoindoles have emerged as versatile precursors in the synthesis of spirocyclopropyl oxindoles with high enantio- and diastereoselectivity under conditions of both iminium/enamine and H-bonding catalysis.

TL;DR: In this article, an eight-membered macrocycle of the hemicucurbit[n]uril family, chiral (all-R)-cyclohexanohemicucurb[8]URil (cycHC[8], has been shown to fully encapsulate anions in a 1':'1 ratio, resembling a molecular Pac-Man™.

TL;DR: Enantiomerically pure cyclohexylhemicucurbit[8]uril (cycHC], possessing a barrel-shaped cavity, has been prepared in high yield on a gram scale from either (R,R,N,N')-cyclohex-1,2-diylurea and formaldehyde or cycHC[6].

TL;DR: A new asymmetric organocatalytic synthesis of spirocyclopropane oxindoles has been developed based on the Michael addition of N-Boc-protected 3-chlorooxindole to unsaturated 1,4-dicarbonyl compounds, affording trans-substituted spiro encyclopedia oxindole derivatives in high diastereo- and enantioselectivity.

TL;DR: A computational study of (all-S)-cyclohexylhemicucurbit[6]uril and its complexes with anions, the proton (H(+)) and non-dissociated acid (HCl, HBr, HI and HCOOH) guests was performed and quantum theory of atoms in molecules was used to gain insight into guest-host interactions.