Mario Thevis

TL;DR: Since 2002 new 'designer' steroids such as prostanozol, methasterone, androstatrienedione etc have been offered on the nutritional supplement market and also cross-contamination with these steroids are expected.

TL;DR: Pharmaceutical (application of endogenous steroids and various pharmaceutical preparations), technical (hydrolysis, derivatization, matrix), and biological (bacterial activities, enzyme side activities) issues are reviewed.

TL;DR: It is shown that deletion of Δ6‐fatty acid desaturase (FADS2) gene expression in the mouse abolishes the initial step in the enzymatic cascade of PUFA synthesis, and is anticipated that FADS2 will become a major focus in membrane, haemostasis, inflammation and atherosclerosis research.

TL;DR: The versatility of modern mass spectrometers enable specific as well as comprehensive measurements allowing sports drug testing laboratories to determine the misuse of therapeutics such as anabolic-androgenic steroids, stimulants, masking agents or so-called designer drugs in athletes' blood or urine specimens, and a selection of recent developments is summarized in this review.

TL;DR: The application of a comprehensive gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/IRMS)-based method for stable carbon isotopes of endogenous urinary steroids is presented, which covers repeatability and reproducibility.