Klaus Addicks

TL;DR: The chondrodysplasia is characterized by a reduction of the fibrillar collagen network, shortened collagen fibers, and elevated expression of cartilage extracellular matrix genes, suggesting that perlecan protects cartilageextracllular matrix from degradation.

TL;DR: The protective gene is identified, which encodes an N-terminal fragment of ubiquitination factor E4B fused to nicotinamide mononucleotide adenylyltransferase (Nmnat), and it is shown that it confers a dose-dependent block of Wallerian degeneration.

TL;DR: The results indicate that the mouse model for the human genetic disorder incontinentia pigmenti, together with the recent discovery that mutations in the human NEMO gene cause IP, is created.

TL;DR: Progress in this field is hampered by the inability to study cardiomyocytes from early, embryonal hearts because of their very small size and because of the lack of cardiac cell lines that mimic various stages of cardiac development.

TL;DR: It is concluded that Wallerian degeneration progresses rapidly along individual wild-type axons after a heterogeneous latent phase, and challenges earlier models in which clearance of trophic or regulatory factors by axonal transport triggers degeneration.