M
Maritza Jaramillo
Researcher at Institut national de la recherche scientifique
Publications - 34
Citations - 1840
Maritza Jaramillo is an academic researcher from Institut national de la recherche scientifique. The author has contributed to research in topics: EIF4E & Virus. The author has an hindex of 18, co-authored 32 publications receiving 1627 citations. Previous affiliations of Maritza Jaramillo include McGill University & McGill University Health Centre.
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Journal ArticleDOI
Translational control of the innate immune response through IRF-7
Rodney Colina,Mauro Costa-Mattioli,Ryan J.O. Dowling,Maritza Jaramillo,Lee-Hwa Tai,Caroline J. Breitbach,Yvan Martineau,Ola Larsson,Liwei Rong,Yuri V. Svitkin,Andrew P. Makrigiannis,John C. Bell,Nahum Sonenberg +12 more
TL;DR: It is shown that translational control is critical for induction of type-I IFN production in mouse embryonic fibroblasts lacking the translational repressors 4E-BP1 and 4 E-BP2, and the role of4E-BPs as negative regulators oftype-IIFN production, via translational repression of Irf7 mRNA is highlighted.
Journal ArticleDOI
Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection
Maritza Jaramillo,Maria Adelaida Gomez,Ola Larsson,Marina Tiemi Shio,Ivan Topisirovic,Irazú Contreras,Randi Luxenburg,Amy B. Rosenfeld,Rodney Colina,Robert McMaster,Martin Olivier,Mauro Costa-Mattioli,Nahum Sonenberg +12 more
TL;DR: It is shown that the Leishmania protease GP63 cleaves the mammalian/mechanistic target of rapamycin (mTOR), a serine/threonine kinase that regulates the translational repressor 4E-BP1, which serves as major targets for host translational control.
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Hemozoin Induces Macrophage Chemokine Expression through Oxidative Stress-Dependent and -Independent Mechanisms
TL;DR: The molecular mechanisms underlying HZ-inducible macrophage (Mφ) chemokine mRNA expression are investigated to better understand the molecular mechanisms through which parasite components, such as HZ, modulate the immune response during malaria infection.
Journal ArticleDOI
Hemozoin-inducible proinflammatory events in vivo: potential role in malaria infection.
Maritza Jaramillo,Isabelle Plante,Nathalie Ouellet,Karen Vandal,Philippe A. Tessier,Martin Olivier,Martin Olivier +6 more
TL;DR: The results showed that sHZ is a strong modulator of leukocyte recruitment and more specifically of neutrophil and monocyte populations, which could contribute to the immunopathology related to malaria.
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Hemozoin Increases IFN-γ-Inducible Macrophage Nitric Oxide Generation Through Extracellular Signal-Regulated Kinase- and NF-κB-Dependent Pathways
TL;DR: It is suggested that hemozoin exerts a potent synergistic effect on the IFN-γ-inducible NO generation in Mφ via ERK- and NF-κB-dependent pathways.