Mark A. Saper

TL;DR: It is found that enteropathogenic E. coli (EPEC) produces G4C, and an operon containing seven genes is identified, which are required for formation of the capsule, which appears to constitute a polysaccharide secretion system.

TL;DR: The 1.9 Å resolution crystal structure of enteropathogenic Escherichia coli GfcC, a periplasmic protein encoded by the gfc operon, which is essential for assembly of group 4 polysaccharide capsule (O-antigen capsule), is reported.

TL;DR: It is suggested that cycles of phosphorylation and dephosphorylation of Etp, as well as Etk, are involved in the formation of group 4 capsule, providing an additional regulatory layer to the complex control of capsule production.

TL;DR: The results suggest that LysM/M23 EPs are regulated via release of the inhibitory Domain 1 from the M23 active site, likely through conformational rearrangement in vivo, and could open the door for the development of antibiotics that overactivate cell wall digestion processes.

TL;DR: The lipoprotein YraM (gene HI1655) was identified as essential for the growth and viability of H. influenzae but its function is unknown, and its predicted location in the outer membrane, a novel place for such a binding protein, is discussed.