M
Mark D. Moore
Researcher at Anschutz Medical Campus
Publications - 21
Citations - 1589
Mark D. Moore is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Lung & Pulmonary hypertension. The author has an hindex of 13, co-authored 21 publications receiving 1532 citations. Previous affiliations of Mark D. Moore include Kyoto University & United States Department of Veterans Affairs.
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Journal ArticleDOI
Gene Expression Patterns in the Lungs of Patients With Primary Pulmonary Hypertension A Gene Microarray Analysis
Mark W. Geraci,Mark D. Moore,Tracy L. Gesell,Michael E. Yeager,Lori Alger,Heiko A. Golpon,Bifeng Gao,James E. Loyd,Rubin M. Tuder,Norbert F. Voelkel +9 more
TL;DR: It is concluded that the microarray gene expression technique is a new and useful molecular tool that provides novel information pertinent to a better characterization and understanding of the pathobiology of the distinct clinical phenotypes of pulmonary hypertension.
Journal ArticleDOI
Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension
Mark W. Geraci,Bifeng Gao,David Shepherd,Mark D. Moore,Jay Y. Westcott,Karen A. Fagan,Lori Alger,Rubin M. Tuder,Norbert F. Voelkel +8 more
TL;DR: It is concluded that PGIS plays a major role in modifying the pulmonary vascular response to chronic hypoxia, which has important implications for the pathogenesis and treatment of severe pulmonary hypertension.
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Gene Microarray Analysis of Peripheral Blood Cells in Pulmonary Arterial Hypertension
Todd M. Bull,Christopher D. Coldren,Mark D. Moore,Sylk Sotto-Santiago,David V. Pham,S. Patrick Nana-Sinkam,Norbert F. Voelkel,Mark W. Geraci +7 more
TL;DR: Microarray expression profiling of peripheral blood cells can discriminate between patients with PAH and normal volunteers, and these findings may have important implications toward diagnosis, screening, and pathogenesis of this disease.
Journal ArticleDOI
Hypoxia induces different genes in the lungs of rats compared with mice
Yasushi Hoshikawa,Patrick Nana-Sinkam,Mark D. Moore,Sylk Sotto-Santiago,Tzulip Phang,Robert L. Keith,Kenneth G. Morris,Takashi Kondo,Rubin M. Tuder,Norbert F. Voelkel,Mark W. Geraci +10 more
TL;DR: It is proposed that a balance between over- and under-expression of a selective group of genes may be responsible for lung vascular remodeling and vascular tone control.
Journal ArticleDOI
Prostacyclin Receptor-dependent Modulation of Pulmonary Vascular Remodeling
Yasushi Hoshikawa,Yasushi Hoshikawa,Norbert F. Voelkel,Norbert F. Voelkel,Tracy L. Gesell,Tracy L. Gesell,Mark D. Moore,Mark D. Moore,Kenneth G. Morris,Kenneth G. Morris,Lori Alger,Lori Alger,Shuh Narumiya,Mark W. Geraci,Mark W. Geraci +14 more
TL;DR: The results indicate that PGI(2) and its receptor play an important role in the regulation of hypoxia-induced pulmonary vascular remodeling, and that the absence of a functional receptor worsens pulmonary hypertension.