Robert L. Keith

TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.

TL;DR: The A/J mouse-urethane model reflects significant molecular details of human lung AC, and comparison of changes in orthologous gene expression may provide novel insights into lung carcinogenesis.

TL;DR: Fluorescence bronchoscopy in smokers at high risk for lung cancer observed a unique lesion consisting of capillary blood vessels closely juxtaposed to and projecting into metaplastic or dysplastic squamous bronchial epithelium, angiogenic squamous dysplasia (ASD), a qualitatively distinct form of angiogenesis in which there is architectural rearrangement of the capillary microvasculature.

TL;DR: It is proposed that a balance between over- and under-expression of a selective group of genes may be responsible for lung vascular remodeling and vascular tone control.

TL;DR: Prospective trials are needed to answer important questions, such as the role of induction therapy in patients with potentially resectable stage IIIB disease, and the questions of optimal chemotherapy agents and radiation fractionation schedule.