Determination of sets of solute descriptors from chromatographic measurements

Sweat potentially contains a wealth of physiologically relevant information, but has traditionally been an underutilized resource for non-invasive health monitoring. Recent advances in wearable sweat sensors have overcome many of the historic drawbacks of sweat sensing and such sensors now offer methods of gleaning molecular-level insight into the dynamics of our bodies. Here we review key developments in sweat sensing technology. We highlight the potential value of sweat-based wearable sensors, examine state-of-the-art devices and the requirements of the underlying components, and consider ways to tackle data integrity issues within these systems. We also discuss challenges and opportunities for wearable sweat sensors in the development of personalized healthcare.

/pdf/wearable-sweat-sensors-1kttf2vc0w.pdf

Wearable sweat sensors

Polarity of ionic liquids determined empirically by means of solvatochromic pyridinium N-phenolate betaine dyes

Chiral recognition by enantioselective liquid chromatography: Mechanisms and modern chiral stationary phases

The chemical interpretation and practice of linear solvation energy relationships in chromatography

https://www.cell.com/biophysj/pdf/S0006-3495(06)72586-3.pdf

Cholesterol effect on the dipole potential of lipid membranes.

Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential.

We have studied the dipolarity/polarizability (π*), hydrogen bond donor acidity (α), and hydrogen bond acceptor basicity (β) of sodium dodecyl sulfate (SDS) micelles using the Kamlet−Taft solvatochromic comparison method. The micellar environments of solubilized indicator molecules are quite polar (π* = 1.06) and have strong hydrogen bond donating ability (α = 0.87) and moderate hydrogen bond accepting ability (β = 0.40). Both the high dipolarity and especially the strong hydrogen bond acidity support previous work that indicates water is present in the indicators' micellar microenvironments. In contrast to many previous UV−vis spectroscopic studies of the polarity of SDS micelles, we have resolved the recorded micellar spectra so as to obtain the micellar spectrum of the indicators free from contributions of the indicator in the accompanying aqueous phase. This study was conducted to rationalize and complement linear solvation energy relationship (LSER) studies of partitioning in SDS micellar systems whi...

Study of the polarity and hydrogen bond ability of sodium dodecyl sulfate micelles by the kamlet-taft solvatochromic comparison method

We have studied the dipolarity/polarizability (π*), hydrogen-bond donor acidity (α), and hydrogen-bond acceptor basicity (β) of dodecyltrimethylammonium bromide (DTAB) micelles using the Kamlet−Taft solvatochromic comparison method. DTAB micelles were found to be quite polar (π* = 1.02), to have relatively strong hydrogen-bond donating ability (α = 0.700), and to have moderate hydrogen bond accepting ability (β = 0.486). These values are compared to the π*-, α-, and β-values of sodium dodecyl sulfate (SDS) micelles obtained in a previous solvatochromic study and are found to be qualitatively consistent with linear solvation energy relationship studies of both SDS and DTAB micellar systems. The chemical interpretation of these parameters and the nature of DTAB micelles which they reflect are discussed. By comparison to the solvatochromic parameters of representative pure solvents such as DMSO (π = 1.00), 2-propanol (α = 0.69), and ethylbenzoate (β = 0.43), it is evident that the micellar environments obser...

Mark F. Vitha

Papers

The chemical interpretation and practice of linear solvation energy relationships in chromatography

Cholesterol effect on the dipole potential of lipid membranes.

Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential.

Study of the polarity and hydrogen bond ability of sodium dodecyl sulfate micelles by the kamlet-taft solvatochromic comparison method

Study of the Polarity and Hydrogen-Bond Ability of Dodecyltrimethylammonium Bromide Micelles by the Kamlet−Taft Solvatochromic Comparison Method