M
Mark J. Tomishima
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 47
Citations - 7941
Mark J. Tomishima is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 25, co-authored 46 publications receiving 6916 citations. Previous affiliations of Mark J. Tomishima include Kettering University.
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Journal ArticleDOI
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Stuart M. Chambers,Christopher A. Fasano,Eirini P. Papapetrou,Mark J. Tomishima,Michel Sadelain,Lorenz Studer +5 more
TL;DR: Noggin/SB431542-based neural induction should facilitate the use of hES and hiPS cells in regenerative medicine and disease modeling and obviate the need for protocols based on stromal feeders or embryoid bodies.
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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs
Gabsang Lee,Eirini P. Papapetrou,Hyesoo Kim,Stuart M. Chambers,Mark J. Tomishima,Christopher A. Fasano,Yosif Ganat,Jayanthi Menon,Fumiko Shimizu,Agnes Viale,Viviane Tabar,Michel Sadelain,Lorenz Studer +12 more
TL;DR: The derivation of patient-specific FD-iPSCs and the directed differentiation into cells of all three germ layers including peripheral neurons are reported, illustrating the promise of iPSC technology for gaining new insights into human disease pathogenesis and treatment.
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Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
Justine D. Miller,Yosif Ganat,Sarah Kishinevsky,Robert L. Bowman,Becky Liu,Edmund Y. Tu,Pankaj Mandal,Pankaj Mandal,Elsa Vera,Jae-Won Shim,Sonja Kriks,Tony Taldone,Noemi Fusaki,Mark J. Tomishima,Dimitri Krainc,Teresa A. Milner,Teresa A. Milner,Derrick J. Rossi,Derrick J. Rossi,Lorenz Studer +19 more
TL;DR: It is suggested that progerin-induced aging can be used to reveal late-onset age-related disease features in hiPSC-based disease models.
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Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation
Eirini P. Papapetrou,Mark J. Tomishima,Stuart M. Chambers,Yvonne Mica,Evan Reed,Jayanthi Menon,Viviane Tabar,Qianxing Mo,Lorenz Studer,Michel Sadelain +9 more
TL;DR: The vector system described here presents a powerful tool for mechanistic studies of reprogramming and the optimization of hiPSC generation as well as defining the optimal stoichiometry of RF expression to be highly sensitive to Oct4 dosage.
Journal ArticleDOI
Derivation of neural crest cells from human pluripotent stem cells
TL;DR: In this article, the authors provide protocols for the step-wise differentiation of human embryonic stem cells (hESCs) or human induced pluripotent stem cells(hiPSCs) into neuroectodermal and neural crest (NC) cells using either the MS5 coculture system or a novel defined culture method based on pharmacological inhibition of bone morphogenetic protein and transforming growth factor-beta signaling pathways.