M
Mark J. Wigglesworth
Researcher at Research Triangle Park
Publications - 3
Citations - 1883
Mark J. Wigglesworth is an academic researcher from Research Triangle Park. The author has contributed to research in topics: G protein-coupled receptor & Agonist. The author has an hindex of 1, co-authored 1 publications receiving 1585 citations.
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Journal ArticleDOI
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Andrew J. Brown,Susan M. Goldsworthy,Ashley A. Barnes,Michelle M. Eilert,Lili Tcheang,Dion A. Daniels,Alison I. Muir,Mark J. Wigglesworth,Ian Kinghorn,Neil J. Fraser,Nicholas B. Pike,Jay C. Strum,Klaudia Steplewski,Paul R. Murdock,Julie C. Holder,Fiona H. Marshall,Philip G. Szekeres,Shelagh Wilson,Diane M. Ignar,Steve M. Foord,Alan Wise,Simon J. Dowell +21 more
TL;DR: GPR41 was expressed primarily in adipose tissue, whereas the highest levels of GPR43 were found in immune cells, and was activated by similar ligands but with differing specificity for carbon chain length, with pentanoate being the most potent agonist.
Journal ArticleDOI
Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias
Abigail Pearce,Theo Redfern-Nichols,Matthew Harris,David R. Poyner,Mark J. Wigglesworth,Graham Ladds +5 more
TL;DR: The results represent the first systematic analysis of the importance of β-arrestins and GRKs in CLR-RAMP signal transduction and pave the way for further investigation regarding other Class B1 GPCRs.
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Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors
TL;DR: This work optimized the repressed transactivator yeast two-hybrid system to further develop it as part of a versatile yeast-based drug discovery platform and validated it using HIF-1, demonstrating both fluorescence-based and auxotrophy-based selections that could detect Hif-1β dimerization inhibition.