M
Mark L. McCleland
Researcher at University of Virginia
Publications - 8
Citations - 2903
Mark L. McCleland is an academic researcher from University of Virginia. The author has contributed to research in topics: Kinetochore & NDC80. The author has an hindex of 6, co-authored 7 publications receiving 2782 citations.
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Journal ArticleDOI
Measuring the stoichiometry and physical interactions between components elucidates the architecture of the vertebrate kinetochore.
TL;DR: The present study characterizes numerous precursors of kinetochore assembly in a system free of centromeric chromatin, Xenopus extracts to provide a model for the structural architecture and assembly pathway of the vertebrate kinetchore.
Journal ArticleDOI
Clinical efficacy of atezolizumab plus bevacizumab and chemotherapy in KRAS-mutated non-small cell lung cancer with STK11, KEAP1, or TP53 comutations: subgroup results from the phase III IMpower150 trial
Howard West,Mark L. McCleland,Federico Cappuzzo,Martin Reck,Tony Mok,Robert M. Jotte,Makoto Nishio,Eugene Kim,S. Morris,Wei Zhou,David S. Shames,Meghna Das Thakur,Geetha Shankar,Mark A. Socinski +13 more
TL;DR: The results suggest that atezolizumab combined with bevacizumAB and chemotherapy is an efficacious first-line treatment in metastatic NSCLC subgroups with mKRAS and co-occurring STK11 and/or KEAP1 or TP53 mutations and/ or high PD-L1 expression.
Book ChapterDOI
Purification of the Ndc80 kinetochore subcomplex from Xenopus eggs.
TL;DR: A purification scheme using Xenopus egg extracts to isolate Coomassie-stainable amounts of the xNdc80 kinetochore complex and can be adapted for purification of other protein complexes.