M
Mark M. Metzstein
Researcher at University of Utah
Publications - 22
Citations - 3018
Mark M. Metzstein is an academic researcher from University of Utah. The author has contributed to research in topics: Nonsense-mediated decay & Gene. The author has an hindex of 16, co-authored 22 publications receiving 2858 citations. Previous affiliations of Mark M. Metzstein include Laboratory of Molecular Biology & Medical Research Council.
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Journal ArticleDOI
Genetics of programmed cell death in C. elegans: past, present and future
TL;DR: The conservation of the central cell-death pathway suggests that additional genetic analyses of programmed cell death in C. elegans will help answer questions not only for this nematode but also for other organisms, including ourselves.
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The C. elegans genome sequencing project: a beginning.
John Sulston,Zijin Du,K. Thomas,Richard K. Wilson,LaDeana W. Hillier,Rodger Staden,Nicolette D. Halloran,Philip Green,Jean Thierry-Mieg,L. Qiu,S. Dear,Alan Coulson,M. Craxton,R. Durbin,M. Berks,Mark M. Metzstein,T. Hawkins,R. Ainscough,Robert H. Waterston +18 more
TL;DR: The long-term goal of this project is the elucidation of the complete sequence of the Caenorhabditis elegans genome and a strategy implemented that is amenable to large-scale sequencing.
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The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila.
Hsiao Lan Liang,Chung Yi Nien,Hsiao Yun Liu,Mark M. Metzstein,Nikolai Kirov,Christine Rushlow +5 more
TL;DR: The zinc-finger protein Zelda (Zld; Zinc-finger early Drosophila activator) binds specifically to these sites and is capable of activating transcription in transient transfection assays, suggesting that Zld may also regulate maternal RNA degradation during the maternal-to-zygotic transition.
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A survey of expressed genes in Caenorhabditis elegans.
Robert H. Waterston,Charles E. Martin,M. Craxton,C. Huynh,Alan Coulson,LaDeana W. Hillier,Richard Durbin,Philip Green,Ratna Shownkeen,Nicolette D. Halloran,Mark M. Metzstein,T. Hawkins,Richard K. Wilson,Mary Berks,Zijin Du,K. Thomas,Jean Thierry-Mieg,John Sulston +17 more
TL;DR: The result is the identification of about 1,200 of the estimated 15,000 genes of C. elegans, providing a more accurate estimate of the total number of genes in the organism than has hitherto been available.
Journal ArticleDOI
Branching morphogenesis of the Drosophila tracheal system.
TL;DR: Mapping of the cell movements and shape changes during the sprouting process has revealed that distinct mechanisms of epithelial migration and tube formation are used at each stage of branching, identifying a general program in which a fibroblast growth factor (FGF) and fibro Blast growth factor receptor (FGFR) are used repeatedly to control branch budding and outgrowth.