M
Mark P. Styczynski
Researcher at Georgia Institute of Technology
Publications - 80
Citations - 1735
Mark P. Styczynski is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 18, co-authored 66 publications receiving 1304 citations. Previous affiliations of Mark P. Styczynski include Massachusetts Institute of Technology & Yerkes National Primate Research Center.
Papers
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Journal ArticleDOI
Dynamic and tunable metabolite control for robust minimal-equipment assessment of serum zinc
TL;DR: Tunable, fast-responding sensors to control production of metabolic pigments are developed and used to assess zinc deficiency in a low-cost, minimal equipment fashion.
Journal ArticleDOI
Metabolic modeling helps interpret transcriptomic changes during malaria.
Yan Tang,Anuj Gupta,Swetha Garimalla,Mary R. Galinski,Mark P. Styczynski,Luis L. Fonseca,Eberhard O. Voit +6 more
TL;DR: A model-based interpretation of expression data of genes coding for enzymes associated with purine metabolism obtained during infections of rhesus macaques with the malaria parasite reveals clear patterns of flux redistribution within the purine pathway that are consistent between the two malaria pathogens.
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Integrative analysis associates monocytes with insufficient erythropoiesis during acute Plasmodium cynomolgi malaria in rhesus macaques.
Yan Tang,Yan Tang,Chester J. Joyner,Monica Cabrera-Mora,Celia L. Saney,Stacey A. Lapp,Mustafa V. Nural,Mustafa V. Nural,Suman B. Pakala,Suman B. Pakala,Jeremy D. DeBarry,Jeremy D. DeBarry,Stephanie Soderberg,Jessica C. Kissinger,Tracey J. Lamb,Tracey J. Lamb,Mary R. Galinski,Mary R. Galinski,Mark P. Styczynski,Mark P. Styczynski +19 more
TL;DR: The possibility that malarial anaemia may be driven by monocyte-associated disruption of GATA1/GATA2 function in erythroid progenitors resulting in insufficient erythropoiesis during acute infection is suggested.
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Precise control of lycopene production to enable a fast-responding, minimal-equipment biosensor.
TL;DR: The approaches used here demonstrate the disconnect between fluorescent and metabolite reporters, help enable the use of lycopene as a reporter, and are likely generalizable to other systems that require precise control of metabolite production.
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Metabolomics Analysis of the Toxic Effects of the Production of Lycopene and Its Precursors
TL;DR: The metabolic impacts of producing low, non-toxic levels of lycopene are of much smaller magnitude than the typical metabolic changes inherent to batch growth, and metabolomics is used to study differences in metabolism caused by the time of mevalonate pathway induction and the presence of the lycopenes biosynthesis genes.