M
Mark S. Bolgar
Researcher at Bristol-Myers Squibb
Publications - 34
Citations - 535
Mark S. Bolgar is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Mass spectrometry & Electrospray ionization. The author has an hindex of 11, co-authored 34 publications receiving 471 citations. Previous affiliations of Mark S. Bolgar include Stevens Institute of Technology.
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Degradation of brain natriuretic peptide by neutral endopeptidase: species specific sites of proteolysis determined by mass spectrometry.
TL;DR: Brain natriuretic peptide from 3 different species was cleaved by neutral endopeptidase (NEP) and the products separated by HPLC and the newly formed products were identified by fast atom bombardment or nebulizer-assisted electrospray mass spectrometry to elucidate the sites of proteolysis.
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Identification of the serine residue at the active site of the herpes simplex virus type 1 protease
TL;DR: Mass spectrometric studies and sequencing analysis by Edman degradation identified Ser-129 as the residue modified by DFP and this residue and the region in which it is found is highly conserved among the herpes viral proteases.
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In vitro activity of the herpes simplex virus type 1 protease with peptide substrates
C.L. DiIanni,Claudio Mapelli,D A Drier,Jonglin Tsao,Sesha Natarajan,Douglas James Riexinger,Stephen M. Festin,Mark S. Bolgar,Gregory Yamanaka,S P Weinheimer +9 more
TL;DR: It is demonstrated that peptides corresponding to each of these cleavage sites are substrates for recombinant HSV protease-glutathione S-transferase fusion protein in vitro by high performance liquid chromatography analysis of cleavage reactions.
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Desorption Ionization by Charge Exchange (DICE) for Sample Analysis under Ambient Conditions by Mass Spectrometry
TL;DR: An ambient pressure ionization technique for mass spectrometric analysis of substances present on solid surfaces was developed and was shown to desorb and generate positively charged molecular ions from compounds that are not readily ionized by some other ambient methods, under positive-ion generation mode.
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Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis.
TL;DR: It is recommended that multiple SRM transitions be monitored during mobile phase screening, with the MS/MS parameters used for each SRM optimized for the composition of the mobile phase (pH, organic percentage, and ionic strength) in which the analyte elutes.