Markku Pelto-Huikko

TL;DR: It is suggested that the Aire gene is not necessary for normal T cell education and development, while a defect in immune response detected in challenged Aire-/- mice underlines the crucial role of AIRE/Aire in maintaining homeostatic regulation in the immune system.

TL;DR: The recent studies have begun to elucidate the substrate specificity and the mechanisms that control ADAM-mediated shedding events that regulate, for example, growth-factor and Notch signalling, and the processing of the amyloid precursor protein.

TL;DR: The coexpression of ERβ with ERα and PR as well as its association with the other indicators of low biological aggressiveness of breast cancer suggest that ERβ-positive tumors are likely to respond to hormonal therapy.

TL;DR: It is shown that HEK-Trx2 cells are more resistant toward etoposide and more sensitive toward rotenone, an inhibitor of complex I of the respiratory chain, suggesting that Trx2 plays an important role in the regulation of the mitochondrial membrane potential.

TL;DR: Confocal and electron microscopic analysis suggested that a large portion of aFGF immunoreactivity was associated with the cytoplasmic face of neuronal membranes, consistent with the hypothesis that aF GF is a sequestered growth factor.