M
Markus J. Ege
Researcher at Ludwig Maximilian University of Munich
Publications - 111
Citations - 8932
Markus J. Ege is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Asthma & Allergy. The author has an hindex of 41, co-authored 105 publications receiving 7711 citations. Previous affiliations of Markus J. Ege include Wacker Chemie & University of Ulm.
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Journal ArticleDOI
The asthma epidemic.
TL;DR: Evidence of a plateau in the prevalence of asthma in many Western countries and the evidence of possible causal relations to factors such as air pollution, obesity, diet, and exposure to infections, antibiotics, and allergens is found.
Journal ArticleDOI
Exposure to Environmental Microorganisms and Childhood Asthma
Markus J. Ege,Melanie Mayer,Anne-Cécile Normand,Jon Genuneit,William O.C.M. Cookson,Charlotte Braun-Fahrländer,Dick Heederik,Renaud Piarroux,Erika von Mutius +8 more
TL;DR: Children living on farms had lower prevalences of asthma and atopy and were exposed to a greater variety of environmental microorganisms than the children in the reference group, and this exposure explains a substantial fraction of the inverse relation between asthma and growing up on a farm.
Journal ArticleDOI
Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children.
Markus J. Ege,Christian Bieli,Remo Frei,Robert Theodoor van Strien,Josef Riedler,E. Üblagger,D. Schram-Bijkerk,Bert Brunekreef,Marianne van Hage,Annika Scheynius,Göran Pershagen,Marcus R. Benz,Roger Lauener,Erika von Mutius,Charlotte Braun-Fahrländer +14 more
TL;DR: Maternal exposure to an environment rich in microbial compounds might protect against the development of atopic sensitization and lead to upregulation of receptors of the innate immune system in offspring.
Journal ArticleDOI
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
Martijn J. Schuijs,Monique Willart,Karl Vergote,Delphine Gras,Kim Deswarte,Markus J. Ege,Filipe Branco Madeira,Rudi Beyaert,Geert van Loo,Franz Bracher,Erika von Mutius,Pascal Chanez,Bart N. Lambrecht,Bart N. Lambrecht,Hamida Hammad +14 more
TL;DR: It is shown that chronic exposure to low-dose endotoxin or farm dust protects mice from developing house dust mite–induced asthma, and a single-nucleotide polymorphism in the gene encoding A20 was associated with allergy and asthma risk in children growing up on farms.
Journal ArticleDOI
Not all farming environments protect against the development of asthma and wheeze in children
Markus J. Ege,Remo Frei,Christian Bieli,D. Schram-Bijkerk,Marco Waser,Marcus R. Benz,Gertraud Weiss,Fredrik Nyberg,Fredrik Nyberg,Marianne van Hage,Göran Pershagen,Bert Brunekreef,Josef Riedler,Roger Lauener,Charlotte Braun-Fahrländer,Erika von Mutius +15 more
TL;DR: The protective effect of being raised in a farm environment was ascribed to distinct exposures and levels of endotoxin and extracellular polysaccharides were related to the health outcomes independently of the farm exposures.