M
Markus Schnare
Researcher at Yale University
Publications - 3
Citations - 2133
Markus Schnare is an academic researcher from Yale University. The author has contributed to research in topics: Pattern recognition receptor & Innate immune system. The author has an hindex of 3, co-authored 3 publications receiving 2090 citations. Previous affiliations of Markus Schnare include Howard Hughes Medical Institute.
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Journal ArticleDOI
Toll-like receptors control activation of adaptive immune responses.
Markus Schnare,Markus Schnare,Gregory M. Barton,Gregory M. Barton,Agnieszka Czopik Holt,Kiyoshi Takeda,Shizuo Akira,Ruslan Medzhitov,Ruslan Medzhitov +8 more
TL;DR: It is shown that MyD88-deficient mice have a profound defect in the activation of antigen-specific T helper type 1 (TH1) but not TH2 immune responses, suggesting that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity.
Journal ArticleDOI
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
Lena Alexopoulou,Venetta Thomas,Markus Schnare,Yves Lobet,Juan Anguita,Robert T. Schoen,Ruslan Medzhitov,Erol Fikrig,Richard A. Flavell +8 more
TL;DR: Data indicate that TLR1 and TLR2 are required for lipoprotein recognition and that defects in theTLR1/2 signaling pathway may account for human hyporesponsiveness to OspA vaccination.
Journal ArticleDOI
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88.
TL;DR: It is reported that recognition of CpG DNA requires MyD88, an adaptor protein involved in signal transduction by the Toll-like receptors (TLRs), essential components of innate immune recognition in both Drosophila and mammals.