M
Marlies E. Oomen
Researcher at University of Massachusetts Medical School
Publications - 14
Citations - 628
Marlies E. Oomen is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 6, co-authored 14 publications receiving 385 citations. Previous affiliations of Marlies E. Oomen include University Medical Center Groningen.
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Journal ArticleDOI
Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization
Elizabeth H. Finn,Gianluca Pegoraro,Hugo B. Brandão,Anne-Laure Valton,Marlies E. Oomen,Job Dekker,Leonid A. Mirny,Tom Misteli +7 more
TL;DR: High-throughput optical mapping of several hundred intra-chromosomal interactions in individual human fibroblasts demonstrates low association frequencies, which are determined by genomic distance, higher-order chromatin architecture, and chromatin environment.
Journal ArticleDOI
CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning.
TL;DR: Combining live-cell imaging, fluorescence recovery after photobleaching, and single molecule tracking showed that almost all CTCF chromatin binding is lost in prometaphase, which reveals that CTCf sites, key architectural cis-elements, display cell cycle stage-dependent dynamics in factor binding and nucleosome positioning.
Journal ArticleDOI
Systematic evaluation of chromosome conformation capture assays.
Betul Akgol Oksuz,Liyan Yang,Sameer Abraham,Sergey V. Venev,Nils Krietenstein,Krishna Mohan Parsi,Hakan Ozadam,Hakan Ozadam,Marlies E. Oomen,Ankita Nand,Hui Mao,Ryan M.J. Genga,René Maehr,Oliver J. Rando,Leonid A. Mirny,Leonid A. Mirny,Johan H. Gibcus,Job Dekker,Job Dekker +18 more
TL;DR: In this paper, an improved Hi-C protocol (Hi-C 3.0) was proposed to detect both loops and compartments relatively effectively. But the performance of this protocol was limited by the cross-linking chemistry and chromatin fragmentation strategies.
Journal ArticleDOI
Epigenetic characteristics of the mitotic chromosome in 1D and 3D.
Marlies E. Oomen,Job Dekker +1 more
TL;DR: An overview of the chromosomal organization and epigenetic characteristics of interphase and mitotic chromatin in vertebrates is given and different ways in which mitotic bookmarking enables epigenetic memory of the features of inter phase chromatin through mitosis are described.
Posted ContentDOI
CTCF sites display cell cycle dependent dynamics in factor binding and nucleosome positioning
TL;DR: This work reveals that CTCF sites, a key architectural cis-element of the genome, display cell cycle stage-dependent dynamics in factor binding and nucleosome positioning, and contributes to loss of TADs and C TCF loops during mitosis.