Marta Palmieri

TL;DR: Modulation of four proteins, of particular interest are the two downregulated proteins nucleophosmin and translationally controlled tumor protein, as well as the upregulated proteins programmed cell death protein 5 and stathmin, are consistent with the observation that TSA is able to inhibit cell growth of Paca44 by causing cell cycle arrest at the G2 phase and apoptotic cell death.

TL;DR: The present data are in agreement with previous proteomic analyses performed on pancreatic ductal carcinoma cell lines and place histone‐deacetylases inhibitors among the potentially most powerful drugs for the treatment of pancreatic tumors.

TL;DR: Results and the consideration that DSF is already used in clinics strongly support the GEM and DSF/Zn combination as a new approach to overcoming pancreatic cancer resistance to standard chemotherapy.

TL;DR: A concerted high local invasion of parenchymal cells into the CSC‐derived vascular network suggests that a symbiotic relationship between the parenchymal cells and theCSCs underlies the initiation and maintenance of early PDAC infiltration and metastasis.

TL;DR: The results suggest that the resistance of fibroblasts to the cytotoxic action of PDTC may be related to the up-regulation of p53-dependent antioxidant genes.