Rosa Angela Cardone

TL;DR: This work has shown that NHE1 regulates formation of invadopodia — cell structures that mediate tumour cell migration and invasion that are activated in cancer cells and contribute to tumour formation and progression.

TL;DR: A concordance among NHE1 localization, the generation of a well‐defined acidic extracellular pH in the nanospace surrounding invadopodia, and matrix‐degrading activity at invadobodia of human malignant breast carcinoma cells is shown, providing a structural basis for the role of NHE 1 in invasion and identifying NHE2 as a strategic target for therapeutic intervention.

TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to Epstein-Barr virus.

TL;DR: NHE1 pharmaceutical inhibition by new and potent NHE1 inhibitors represents a potential and highly selective target in anticancer therapy and cariporide could become a new, slightly toxic and effective anticancer agent in different human malignancies.

TL;DR: It is concluded that NHERF1 overexpression enhances the invasive phenotype in breast cancer cells, both alone and in synergy with exposure to the tumor microenvironment, via the coordination of PKA-gated RhoA/p38 signaling.