M
Martijn Zwama
Researcher at Osaka University
Publications - 9
Citations - 405
Martijn Zwama is an academic researcher from Osaka University. The author has contributed to research in topics: Efflux & Gene. The author has an hindex of 5, co-authored 7 publications receiving 295 citations. Previous affiliations of Martijn Zwama include University of Groningen.
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Journal ArticleDOI
Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function
Helgi I. Ingólfsson,Pratima Thakur,Karl F. Herold,E. Ashley Hobart,Nicole Ramsey,Xavier Periole,Djurre H. de Jong,Martijn Zwama,Duygu Yilmaz,Katherine C. Hall,Thorsten Maretzky,Hugh C. Hemmings,Carl P. Blobel,Siewert J. Marrink,Armagan Kocer,Jon T. Sack,Olaf S. Andersen +16 more
TL;DR: The results suggest that many effects of amphiphilic phytochemicals are due to cell membrane perturbations, rather than specific protein binding, which is consistent with a common, bilayer-mediated mechanism.
Journal ArticleDOI
Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
Martijn Zwama,Seiji Yamasaki,Ryosuke Nakashima,Keisuke Sakurai,Kunihiko Nishino,Akihito Yamaguchi +5 more
TL;DR: A transport path specific for planar aromatic cations in the E. coli multi-drug transporter AcrB is described, which is connected directly to the deep pocket without first passing the switch-loop and the proximal pocket.
Journal ArticleDOI
Molecular mechanisms of AcrB-mediated multidrug export.
Martijn Zwama,Akihito Yamaguchi +1 more
TL;DR: The current knowledge of AcrB is discussed, and recent advances are discussed, regarding its structure, mechanism of drug transport, substrate recognition, different intramolecular entry pathways and the drug export driven by remote conformational coupling.
Journal ArticleDOI
Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time.
Martijn Zwama,Kunihiko Nishino +1 more
TL;DR: In this article, the authors take a closer look at clinically, environmentally and laboratory-evolved Gram-negative bacterial strains and their decreased drug sensitivity as a result of mutations directly in the RND-type pumps themselves (from Escherichia coli, Salmonella-enterica, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Acinetobacter baumannii and Legionella pneumophila).
Journal ArticleDOI
Phylogenetic and functional characterisation of the Haemophilus influenzae multidrug efflux pump AcrB.
TL;DR: It is found that AcrB-Hi is a relatively ancient efflux pump, which nonetheless can export the same range of antibiotics as its evolved colleague from Escherichia coli, and is hypothesised to be present since ancient promiscuous transporters.