M
Martin A. Read
Researcher at Institute of Cancer Research
Publications - 19
Citations - 1952
Martin A. Read is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Telomerase & G-quadruplex. The author has an hindex of 14, co-authored 19 publications receiving 1861 citations. Previous affiliations of Martin A. Read include King's College London.
Papers
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Journal ArticleDOI
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
Martin A. Read,Richard J. Harrison,B Romagnoli,FA Tanious,SH Gowan,Anthony P. Reszka,WD Wilson,Lloyd R. Kelland,Stephen Neidle +8 more
TL;DR: Calculated relative binding energies predict enhanced selectivity compared with earlier 3,6-disubstituted compounds, as a result of the anilino substituent at the 9-position of the acridine chromophore, which is predicted to lie in a third groove of the quadruplex.
Journal ArticleDOI
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
Sharon Gowan,John R. Harrison,Lisa Patterson,Melanie Valenti,Martin A. Read,Stephen Neidle,Lloyd R. Kelland +6 more
TL;DR: The antitelomerase and antitumor properties of a small-molecule compound designed by computer modeling to interact with and stabilize human G-quadruplex DNA, a structure that may form with telomeric DNA, thereby inhibiting access to telomerase, are described.
Journal ArticleDOI
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.
Philip J. Perry,Martin A. Read,Rhian T. Davies,Sharon Gowan,Anthony P. Reszka,Alexis A. Wood,Lloyd R. Kelland,Stephen Neidle +7 more
TL;DR: This fluorenone series of compounds exhibits a broad range of telomerase inhibitory activity, with the most potent inhibitors displaying levels of activity comparable with other classes of G-quadruplex-interactive agents.
Journal ArticleDOI
G-quadruplexes as therapeutic targets.
Stephen Neidle,Martin A. Read +1 more
TL;DR: Structural and mechanistic aspects of these quadruplex complexes are reviewed here, together with a discussion of the issues of selectivity/potency for quadruplex DNAs vs duplex DNA.
Journal ArticleDOI
Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones
Philip J. Perry,Anthony P. Reszka,Alexis A. Wood,Martin A. Read,Sharon Gowan,Harvinder S. Dosanjh,John O. Trent,Terence C. Jenkins,Lloyd R. Kelland,Stephen Neidle +9 more
TL;DR: In contrast to previous studies directed toward triplex DNA, it is evident that stringent control over positional attachment of substituents is not a necessity for effective telomerase inhibition.