L
Lloyd R. Kelland
Researcher at University College London
Publications - 188
Citations - 18357
Lloyd R. Kelland is an academic researcher from University College London. The author has contributed to research in topics: Cisplatin & Carboplatin. The author has an hindex of 63, co-authored 188 publications receiving 17295 citations. Previous affiliations of Lloyd R. Kelland include St George's Hospital & University of Nottingham.
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The resurgence of platinum-based cancer chemotherapy
TL;DR: Key developments include the elucidation of mechanisms of tumour resistance to these drugs, the introduction of new platinum-based agents (oxaliplatin, satraplatin and picoplatin), and clinical combination studies using platinum drugs with resistance modulators or new molecularly targeted drugs.
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Guidelines for the welfare and use of animals in cancer research
Paul Workman,Eric O. Aboagye,Frances R. Balkwill,Allan Balmain,G Bruder,D.J. Chaplin,John A. Double,Jeffrey I. Everitt,D A H Farningham,D A H Farningham,Martin J. Glennie,Lloyd R. Kelland,V Robinson,Ian J. Stratford,Gillian M. Tozer,Susan A. Watson,Stephen R. Wedge,Suzanne A. Eccles,V Navaratnam,S Ryder +19 more
TL;DR: New guidelines on the welfare and use of animals in cancer research are provided, including recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models and humane endpoints.
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Discovery and development of anticancer aptamers.
TL;DR: The most advanced aptamer in the cancer setting is AS1411, formerly known as AGRO100, which is being administered systemically in clinical trials and seems to involve initial binding to cell surface nucleolin and internalization, leading to an inhibition of DNA replication.
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Short tandem repeat profiling provides an international reference standard for human cell lines
John R. W. Masters,James A. Thomson,Bernadette Daly-Burns,Yvonne Reid,Wilhelm G. Dirks,Phil Packer,Lorraine H. Toji,Tadao Ohno,Hideyuki Tanabe,Colin F. Arlett,Lloyd R. Kelland,Maureen Harrison,Arvind Virmani,Timothy H. Ward,Karen L. Ayres,Paul G. Debenham +15 more
TL;DR: To test a standard method of cell line authentication, 253 human cell lines from banks and research institutes worldwide were analyzed by short tandem repeat profiling, finding that it can provide an international reference standard for every cell line.
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Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
Martin A. Read,Richard J. Harrison,B Romagnoli,FA Tanious,SH Gowan,Anthony P. Reszka,WD Wilson,Lloyd R. Kelland,Stephen Neidle +8 more
TL;DR: Calculated relative binding energies predict enhanced selectivity compared with earlier 3,6-disubstituted compounds, as a result of the anilino substituent at the 9-position of the acridine chromophore, which is predicted to lie in a third groove of the quadruplex.