Showing papers by "Martin Antonio published in 2007"
TL;DR: A new NTS serovar named S. Dingiri was discovered, which possesses an antigenic formula of 17:z:1,6,6 and was sensitive to ampicillin, cefotaxime, chloramphenicol, ciprofloxacin, cotrimoxazole and tetracycline but resistant to gentamicin, and was ST338.
Abstract: Sixty-two invasive non-typhoidal Salmonella (NTS) isolates from children aged 2-29 months in rural Gambia were examined for serovar prevalence and antimicrobial susceptibility, and characterized using multilocus sequence typing (MLST) of seven genes, aroC, dnaN, hemD, hisD, purE, sucA and thrA. Salmonella enterica serovar Enteritidis was the most common serovar (80.6 %), followed by S. enterica serovar Typhimurium (8.0 %). Thirty-three per cent of the isolates were resistant to all eight antimicrobials tested, including ampicillin (74.2 %), cotrimoxazole (64.5 %) and tetracycline (63 %). A total of 40.3 % of the NTS cases had an initial clinical diagnosis of malaria, whilst 27.3 % had a diagnosis of clinical pneumonia and 18 % had a diagnosis of septicaemia. MLST of NTS resulted in ten different sequence types (STs), of which five were novel, representing five different NTS serovars. In general, STs were restricted to the same serovar. One type (ST11) encompassed 80.6 % of the NTSs. A new NTS serovar named S. enterica serovar Dingiri was discovered. S. Dingiri was isolated from a 6-month-old male with an initial clinical diagnosis of malaria but a final clinical diagnosis of anaemia and septicaemia. S. Dingiri, which possesses an antigenic formula of 17:z:1,6, was sensitive to ampicillin, cefotaxime, chloramphenicol, ciprofloxacin, cotrimoxazole and tetracycline but resistant to gentamicin, and was ST338.
61 citations
TL;DR: The re-establishment of continuing surveillance is required to answer the questions raised by this report, and is particularly important in settings like The Gambia, where a booster dose is not given, to determine long-term effects of national immunisation with Hib vaccine.
39 citations
Journal Article•
TL;DR: A rapidly rising ELISPOT count is reported in a 55-year-old man with evidence of Mycobacterium tuberculosis infection prior to the onset of symptoms of disease, illustrating the possible utility of quantitative changes in the ELISpOT count in predicting progression from M. tuberculosis infection to disease.
Abstract: La relation entre les reponses des cellules T aux antigenes mycobacteriens et le risque de progression vers la maladie n'a pas ete bien definie jusqu'ici. Nous rapportons un accroissement rapide du decompte d'ELISPOT chez un homme âge de 55 ans avec des signes d'infection par Mycobacterium tuberculosis avant meme le developpement des symptomes de la maladie. Ce cas illustre l'utilite potentielle des modifications quantitatives du decompte ELISPOT pour la prediction d'une progression d'une infection par M. tuberculosis vers une maladie.
13 citations