R
Roger H. Brookes
Researcher at Sanofi Pasteur
Publications - 66
Citations - 5142
Roger H. Brookes is an academic researcher from Sanofi Pasteur. The author has contributed to research in topics: Mycobacterium tuberculosis & ELISPOT. The author has an hindex of 34, co-authored 65 publications receiving 5020 citations. Previous affiliations of Roger H. Brookes include Medical Research Council & St Thomas' Hospital.
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Journal ArticleDOI
Rapid Effector Function in CD8+ Memory T Cells
Ajit Lalvani,Roger H. Brookes,Sophie Hambleton,Warwick J. Britton,Adrian V. S. Hill,Andrew J. McMichael +5 more
TL;DR: The phenotype of CD8+ T cells, which persist at a low frequency long after recovery from an acute viral infection, suggests that they play a role in protective immunological memory.
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Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis.
Ajit Lalvani,Roger H. Brookes,Robert J. Wilkinson,Adam S. Malin,Ansar A. Pathan,Peter Andersen,Hazel M. Dockrell,Geoffrey Pasvol,Adrian V. S. Hill +8 more
TL;DR: These results provide direct evidence for the involvement of CD8+ cytotoxic T lymphocytes in host defense against M. tuberculosis in humans and support current attempts to generate protective cytot toxic T lymphocyte responses againstM.
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Enhanced Immunogenicity and Protective Efficacy Against Mycobacterium tuberculosis of Bacille Calmette-Guérin Vaccine Using Mucosal Administration and Boosting with a Recombinant Modified Vaccinia Virus Ankara
Nilu Goonetilleke,Helen McShane,Carolyn M. Hannan,Richard J. Anderson,Roger H. Brookes,Adrian V. S. Hill +5 more
TL;DR: It is shown that recombinant modified vaccinia virus Ankara, expressing Mycobacterium tuberculosis Ag 85A (M.85A), strongly boosts bacille Calmette-Guérin (BCG)-induced Ag85A specific CD4+ and CD8+ T cell responses in mice, which support further evaluation of mucosally targeted prime-boost vaccination approaches for tuberculosis.
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Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques
Thomas Lehner,Yufei Wang,Martin Cranage,Lesley A. Bergmeier,Elaine Mitchell,Louisa Tao,Graham Hall,Michael Dennis,Nicola Cook,Roger H. Brookes,Linda S. Klavinskis,Ian Jones,Carl Doyle,Robert Ward +13 more
TL;DR: Protection in macaques immunized with a recombinant SIV envelope gp120 and core p27 vaccine was associated with significant increase in the iliac lymph nodes of lgA antibody–secreting cells to p27 and the chemokines RANTES and MIP–1β.
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1,25-Dihydroxyvitamin D3 Induces Nitric Oxide Synthase and Suppresses Growth of Mycobacterium tuberculosis in a Human Macrophage-Like Cell Line
Kirk A. Rockett,Roger H. Brookes,Irina A. Udalova,Vincent Vidal,Adrian V. S. Hill,Dominic P. Kwiatkowski +5 more
TL;DR: It is found that 1,25-D3 acts to suppress the growth of Mycobacterium tuberculosis in these cells and that this effect is inhibited byNG-monomethyl-l-arginine, suggesting that vitamin D-induced NO production may play a role in the host defense against human tuberculosis.