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René L. Jacobs

Researcher at University of Alberta

Publications -  107
Citations -  5925

René L. Jacobs is an academic researcher from University of Alberta. The author has contributed to research in topics: Choline & Phosphatidylethanolamine N-methyltransferase. The author has an hindex of 37, co-authored 100 publications receiving 4806 citations. Previous affiliations of René L. Jacobs include Canadian Institutes of Health Research & Memorial University of Newfoundland.

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Journal ArticleDOI

The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease.

Jelske N. van der Veen, +5 more
- 01 Sep 2017 - 
TL;DR: Data showing that changes in the PC and/or PE content of various tissues are implicated in metabolic disorders such as atherosclerosis, insulin resistance and obesity is highlighted.
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Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity

Debby P.Y. Koonen, +7 more
- 01 Dec 2007 - 
TL;DR: Increased expression of hepatic CD36 protein in response to DIO is sufficient to exacerbate hepatic triglyceride storage and secretion, suggesting that increased CD36 expression likely plays a causative role in the pathogenesis of type 2 diabetes.
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A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

Amy K. Walker, +13 more
- 11 Nov 2011 - 
TL;DR: The studies identify a conserved regulatory circuit in which SREBP-1 controls genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAMe), and suggest a feedback mechanism whereby maturation of nuclear, transcriptionally active SRE BP-1 is controlled by levels of PC.
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Is it time to reevaluate methyl balance in humans

Lori M. Stead, +4 more
- 01 Jan 2006 - 
TL;DR: It is suggested that creatine synthesis is responsible for a smaller proportion of AdoMet-derived methyl groups than has been suggested and that phosphatidylcholine synthesis via phosphatidethanolamine methyltransferase is a major consumer of these methyl groups.
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Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat.

René L. Jacobs, +3 more
- 01 Dec 1998 - 
TL;DR: The results suggest that insulin is involved in the regulation of plasma homocysteine concentrations by affecting the hepatic transsulfuration pathway, which isinvolved in the catabolism of homocy steine.