M
Martin Granzow
Researcher at Heidelberg University
Publications - 54
Citations - 5466
Martin Granzow is an academic researcher from Heidelberg University. The author has contributed to research in topics: Exome sequencing & Comparative genomic hybridization. The author has an hindex of 25, co-authored 53 publications receiving 4947 citations. Previous affiliations of Martin Granzow include German Cancer Research Center & University Hospital Heidelberg.
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Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan/dexamethasone
Tilmann Bochtler,Ute Hegenbart,Christina Kunz,Axel Benner,Anja Seckinger,Sascha Dietrich,Martin Granzow,Kai Neben,Hartmut Goldschmidt,Anthony D. Ho,Dirk Hose,Anna Jauch,Stefan Schönland +12 more
TL;DR: Gain of 1q21 was identified as an independent adverse prognostic factor in AL amyloidosis patients treated with standard chemotherapy and deletion 13q14 and hyperdiploidy turned out to be prognostically neutral.
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Recurrent CDKN1B (p27) mutations in hairy cell leukemia
Sascha Dietrich,Sascha Dietrich,Jennifer Hüllein,Stanley Chun-Wei Lee,Barbara Hutter,David Gonzalez,Sandrine Jayne,Martin J. S. Dyer,Małgorzata Oleś,Monica Else,Xiyang Liu,Mikolaj Slabicki,Bian Wu,Xavier Troussard,Jan Dürig,Mindaugas Andrulis,Claire Dearden,Christof von Kalle,Martin Granzow,Anna Jauch,Stefan Fröhling,Wolfgang Huber,Manja Meggendorfer,Torsten Haferlach,Anthony D. Ho,Daniela Richter,Benedikt Brors,Hanno Glimm,Estella Matutes,Omar Abdel Wahab,Thorsten Zenz,Thorsten Zenz +31 more
TL;DR: Hairy cell leukemia is identified as having the highest frequency of CDKN1B mutations among cancers and CDNK1B is named as the second most common mutated gene in HCL, suggesting a novel role for alterations in regulation of cell cycle and senescence in H CL with CDKN 1B mutations.
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Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study
Tilmann Bochtler,Ute Hegenbart,Christina Kunz,Axel Benner,Christoph Kimmich,Anja Seckinger,Dirk Hose,Hartmut Goldschmidt,Martin Granzow,Peter Dreger,Anthony D. Ho,Anna Jauch,Stefan Schönland +12 more
TL;DR: T(11;14) positivity in HDM-treated AL patients conferred superior CR rates and hemEFS, and this highlights the impact of therapy on the prognostic role of cytogenetic aberrations.
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Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia.
Tilmann Bochtler,Martin Granzow,Friedrich Stölzel,Christina Kunz,Brigitte Mohr,Mutlu Kartal-Kaess,Mutlu Kartal-Kaess,Katrin Hinderhofer,Christoph E. Heilig,Michael Kramer,Christian Thiede,Volker Endris,Martina Kirchner,Albrecht Stenzinger,Axel Benner,Martin Bornhäuser,Gerhard Ehninger,Anthony D. Ho,Anna Jauch,Alwin Krämer +19 more
TL;DR: Marker chromosomes are indicative of chromothripsis and associated with poor prognosis per se and not merely by association with other adverse cytogenetic features.
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Tumor classification by gene expression profiling: comparison and validation of five clustering methods
TL;DR: This work describes a comparative study of five clustering methods for microarray gene expression profiling of tumors, a computing methodology that discovers and describes meaningful patterns or structures in data.