Mikolaj Slabicki

TL;DR: The approaches described here are generally applicable to high-throughput follow-up analyses of phenotypic screens in mammalian cells and led to the discovery of previously unknown, evolutionarily conserved subunits of the anaphase-promoting complex and the γ-tubulin ring complex—large complexes that are essential for spindle assembly and chromosome segregation.

TL;DR: A genome-scale RNA-mediated interference screen in HeLa cells designed to identify human genes that are important for cell division is reported, and two evolutionarily conserved transcriptional regulatory networks that govern cytokinesis are identified.

TL;DR: The human ZF “degrome” is defined in the context of thalidomide, lenalidomid, and pomalidomides to characterize the ZF-drug-CRBN interaction structurally and functionally and determine whether different thalidmide analogs degrade distinct ZFs.

TL;DR: A genome-scale RNAi screen for a global survey of genes affecting ESC identity via alteration of Oct4 expression shows that the Paf1C binds to promoters of key pluripotency genes, where it is required to maintain a transcriptionally active chromatin structure.

TL;DR: In this paper, the authors present genome-wide data sets for the production of endoribonuclease-prepared short interfering RNAs (esiRNAs) for human, mouse and rat.