M
Martin Mollenhauer
Researcher at Heidelberg University
Publications - 8
Citations - 652
Martin Mollenhauer is an academic researcher from Heidelberg University. The author has contributed to research in topics: Liver regeneration & Colorectal cancer. The author has an hindex of 8, co-authored 8 publications receiving 590 citations. Previous affiliations of Martin Mollenhauer include University Hospital Heidelberg.
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Journal ArticleDOI
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
Murtaza M. Tambuwala,Eoin P. Cummins,Colin R. Lenihan,Judith Kiss,Markus Stauch,Carsten C. Scholz,Peter Fraisl,Felix Lasitschka,Martin Mollenhauer,Sean P. Saunders,Patrick H. Maxwell,Peter Carmeliet,Padraic G. Fallon,Martin Schneider,Cormac T. Taylor +14 more
TL;DR: Genetic loss of PHD1 is protective against colitis through decreased epithelial cell apoptosis and consequent enhancement of intestinal epithelial barrier function, which implies a role forPHD1 as a positive regulator of intestine epithelialcell apoptosis in the inflamed colon.
Journal ArticleDOI
Overexpression of ZEB2 at the Invasion Front of Colorectal Cancer Is an Independent Prognostic Marker and Regulates Tumor Invasion In Vitro
Christoph Kahlert,Saleh Lahes,Praveen Radhakrishnan,Shamik Dutta,Carolin Mogler,Esther Herpel,Karsten Brand,Gunnar Steinert,Martin Schneider,Martin Mollenhauer,Christoph Reissfelder,Fee Klupp,Johannes Fritzmann,Christina Wunder,Axel Benner,Matthias Kloor,Cathrin Huth,Pietro Contin,Alexis Ulrich,Moritz Koch,Juergen Weitz +20 more
TL;DR: Overexpression of ZEB2 at the invasion front correlates with tumor progression and predicts cancer-specific survival in primary colorectal cancer, and may be interesting as biomarker and potential target for treatment of colorective cancer.
Journal ArticleDOI
Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury
Martin Schneider,Katie Van Geyte,Peter Fraisl,Judit Kiss,Julián Aragonés,Massimiliano Mazzone,Heimo Mairbäurl,Katrien De Bock,Nam Ho Jeoung,Martin Mollenhauer,Maria Georgiadou,Tammie Bishop,Carmen Roncal,Andrew Sutherland,Bénédicte F. Jordan,Bernard Gallez,Jürgen Weitz,Robert A. Harris,Patrick H. Maxwell,Myriam Baes,Peter J. Ratcliffe,Peter Carmeliet +21 more
TL;DR: Loss of PHD1 provided tolerance of hepatocytes to acute hypoxia and protected them against I/R-damage, and short-term inhibition ofPHD1 through RNA interference-mediated silencing provided protection against I-R.
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Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis
Judit Kiss,Martin Mollenhauer,Sarah R. Walmsley,Johanna Kirchberg,Praveen Radhakrishnan,Thomas Niemietz,Johanna Dudda,Gunnar Steinert,Moira K. B. Whyte,Peter Carmeliet,Massimiliano Mazzone,Juergen Weitz,Martin Schneider +12 more
TL;DR: It is concluded that impairment of PHD3 enzyme function aggravates the clinical course of abdominal sepsis via HIF-1α– and NF-κB–mediated enhancement of the innate immune response.
Journal ArticleDOI
Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine
Orkhan Isayev,Vanessa Rausch,Vanessa Rausch,Nathalie Bauer,Nathalie Bauer,Li Liu,Li Liu,Pei Fan,Pei Fan,Yiyao Zhang,Yiyao Zhang,Jury Gladkich,Jury Gladkich,Clifford C. Nwaeburu,Clifford C. Nwaeburu,Jürgen Mattern,Martin Mollenhauer,Felix Rückert,Sebastian Zach,Uwe Haberkorn,Wolfgang Gross,Wolfgang Gross,Frank Schönsiegel,Frank Schönsiegel,Alexandr V. Bazhin,Ingrid Herr +25 more
TL;DR: It is proposed that CSCs may be specifically dependent on a high glucose turnover and suggest 3-bromopyruvate for therapeutic intervention.