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Bernard Gallez
Researcher at Université catholique de Louvain
Publications - 339
Citations - 14213
Bernard Gallez is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Tumor Oxygenation & Electron paramagnetic resonance. The author has an hindex of 56, co-authored 322 publications receiving 12660 citations. Previous affiliations of Bernard Gallez include Catholic University of Leuven & Centre national de la recherche scientifique.
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Journal ArticleDOI
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Pierre Sonveaux,Frédérique Végran,Thies Schroeder,Melanie Wergin,Julien Verrax,Zahid N. Rabbani,Christophe De Saedeleer,Kelly M. Kennedy,Caroline Diepart,Bénédicte F. Jordan,Michael J. Kelley,Bernard Gallez,Miriam L. Wahl,Olivier Feron,Mark W. Dewhirst +14 more
TL;DR: In this paper, the authors identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism.
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Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone,Massimiliano Mazzone,Daniela Dettori,Daniela Dettori,Daniela Dettori,Rodrigo Leite de Oliveira,Rodrigo Leite de Oliveira,Sonja Loges,Sonja Loges,Thomas Schmidt,Thomas Schmidt,Bart Jonckx,Bart Jonckx,Ya Min Tian,Anthony A. Lanahan,Patrick J. Pollard,Carmen Ruiz de Almodovar,Carmen Ruiz de Almodovar,Frederik De Smet,Frederik De Smet,Stefan Vinckier,Stefan Vinckier,Julián Aragonés,Julián Aragonés,Koen Debackere,Koen Debackere,Aernout Luttun,Sabine Wyns,Sabine Wyns,Bénédicte F. Jordan,Alberto Pisacane,Bernard Gallez,Maria Grazia Lampugnani,Elisabetta Dejana,Michael Simons,Peter J. Ratcliffe,Patrick H. Maxwell,Peter Carmeliet,Peter Carmeliet +38 more
TL;DR: In this paper, the role of endothelial PHD2 in vessel shaping by implanting tumors in mice was investigated. But, the authors did not find that PHD deficiency did not affect vessel density or lumen size.
Journal ArticleDOI
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
Julián Aragonés,Martin Schneider,Martin Schneider,Martin Schneider,Katie Van Geyte,Katie Van Geyte,Peter Fraisl,Peter Fraisl,Tom Dresselaers,Massimiliano Mazzone,Massimiliano Mazzone,Ruud Dirkx,Serena Zacchigna,Serena Zacchigna,Hélène Lemieux,Nam Ho Jeoung,Diether Lambrechts,Diether Lambrechts,Tammie Bishop,Peggy Lafuste,Peggy Lafuste,Antonio Diez-Juan,Antonio Diez-Juan,Sarah K. Harten,Pieter Van Noten,Katrien De Bock,Carsten Willam,Marc Tjwa,Marc Tjwa,A. Grosfeld,Rachel Navet,Lieve Moons,Lieve Moons,Thierry VandenDriessche,Thierry VandenDriessche,Christophe Deroose,Bhathiya Wijeyekoon,Johan Nuyts,Bénédicte F. Jordan,Robert Silasi-Mansat,Florea Lupu,Mieke Dewerchin,Mieke Dewerchin,Christopher W. Pugh,Phil Salmon,Luc Mortelmans,Bernard Gallez,Frans Gorus,Johan Buyse,Francis Sluse,Robert A. Harris,Erich Gnaiger,Peter Hespel,Paul Van Hecke,Frans Schuit,Paul P. Van Veldhoven,Peter J. Ratcliffe,Myriam Baes,Patrick H. Maxwell,Peter Carmeliet,Peter Carmeliet +60 more
TL;DR: It is shown that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP production through activation of a Pparα pathway.
Journal ArticleDOI
A Mitochondrial Switch Promotes Tumor Metastasis
Paolo E. Porporato,Valéry Payen,Jhudit Pérez-Escuredo,Christophe De Saedeleer,Pierre Danhier,Tamara Copetti,Suveera Dhup,Morgane Tardy,Thibaut Vazeille,Caroline Bouzin,Olivier Feron,Carine Michiels,Bernard Gallez,Pierre Sonveaux +13 more
TL;DR: Two different events, ETC overload and partial ETC inhibition, promote superoxide-dependent tumor cell migration, invasion, clonogenicity, and metastasis, and specific scavenging of mitochondrial superoxide with mitoTEMPO blocked tumor cell Migration and prevented spontaneous tumor metastasis in murine and human tumor models.
Journal ArticleDOI
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Pierre Sonveaux,Pierre Sonveaux,Tamara Copetti,Christophe De Saedeleer,Frédérique Végran,Julien Verrax,Kelly M. Kennedy,Eui Jung Moon,Suveera Dhup,Pierre Danhier,Françoise Frérart,Bernard Gallez,Anthony T. Ribeiro,Carine Michiels,Mark W. Dewhirst,Olivier Feron +15 more
TL;DR: This study finds that blockade of lactate influx into ECs led to inhibition of HIF-1-dependent angiogenesis and identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities.