M
Matthias Kloor
Researcher at University Hospital Heidelberg
Publications - 219
Citations - 10187
Matthias Kloor is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Microsatellite instability & Lynch syndrome. The author has an hindex of 48, co-authored 209 publications receiving 8038 citations. Previous affiliations of Matthias Kloor include German Cancer Research Center & Heidelberg University.
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Journal ArticleDOI
Potential of fecal microbiota for early‐stage detection of colorectal cancer
Georg Zeller,Julien Tap,Anita Y. Voigt,Shinichi Sunagawa,Jens Roat Kultima,Paul I. Costea,Aurelien Amiot,Jürgen Böhm,Francesco Brunetti,Nina Habermann,Rajna Hercog,Moritz Koch,Alain Luciani,Daniel R. Mende,Martin Schneider,Petra Schrotz-King,Christophe Tournigand,Jeanne Tran Van Nhieu,Takuji Yamada,Jürgen Zimmermann,Vladimir Benes,Matthias Kloor,Matthias Kloor,Matthias Kloor,Cornelia M. Ulrich,Cornelia M. Ulrich,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Magnus von Knebel Doeberitz,Iradj Sobhani,Peer Bork,Peer Bork +31 more
TL;DR: CRC‐associated changes in the fecal microbiome at least partially reflected microbial community composition at the tumor itself, indicating that observed gene pool differences may reveal tumor‐related host–microbe interactions.
Journal ArticleDOI
Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy
Niels Halama,Sara Michel,Matthias Kloor,Inka Zoernig,Axel Benner,Anna Spille,Thora Pommerencke,Doeberitz Magnus von Knebel,Gunnar Folprecht,Birgit Luber,Nadine Feyen,Uwe M. Martens,Philipp Beckhove,Sacha Gnjatic,Peter Schirmacher,Esther Herpel,Juergen Weitz,Niels Grabe,Dirk Jaeger +18 more
TL;DR: Analysis of tumor-infiltrating lymphocytes (TIL) in primary human colorectal cancer by in situ immunohistochemical staining supports the hypothesis that the adaptive immune response influences the course of human CRC and extends the impact of the local immune response on the clinical course from the primary tumor also to metastatic lesions.
Journal ArticleDOI
Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers
Yvette Schwitalle,Matthias Kloor,Susanne Eiermann,Michael Linnebacher,Peter Kienle,Hanns Peter Knaebel,Mirjam Tariverdian,Axel Benner,Magnus von Knebel Doeberitz +8 more
TL;DR: Data suggest that FSPs presented by DNA mismatch repair-deficient CRC cells are effectively recognized by the patient's immune system and may explain the characteristic clinicopathologic features of HNPCC-associated but also sporadic MSI-H CRCs.
Journal ArticleDOI
Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study
Marlies Kempers,Roland P. Kuiper,Charlotte W. Ockeloen,Pierre O. Chappuis,Pierre Hutter,Nils Rahner,Hans K. Schackert,Verena Steinke,Elke Holinski-Feder,Monika Morak,Matthias Kloor,Reinhard Büttner,Eugène T P Verwiel,J. Han van Krieken,Iris D. Nagtegaal,Monique Goossens,Rachel S. van der Post,Renee C. Niessen,Rolf H. Sijmons,Irma Kluijt,Frans B. L. Hogervorst,Edward M Leter,Johan J.P. Gille,Cora M. Aalfs,Egbert J.W. Redeker,Frederik J. Hes,Carli M. J. Tops,Bernadette P M van Nesselrooij,Marielle E. van Gijn,Encarna B. Gomez Garcia,Diana Eccles,David J. Bunyan,Sapna Syngal,Elena M. Stoffel,Julie O. Culver,Melanie R. Palomares,Tracy Graham,Lea Velsher,János Papp,Edith Olah,Tsun Leung Chan,Suet Yi Leung,Ad Geurts van Kessel,Lambertus A. Kiemeney,Nicoline Hoogerbrugge,Marjolijn J L Ligtenberg +45 more
TL;DR: The results underscore the effect of mosaic MSH2 deficiency, leading to variable cancer risks, and could form the basis of an optimised protocol for the recognition and targeted prevention of cancer in EPCAM deletion carriers.
Journal ArticleDOI
Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines and cytokines.
Niels Halama,Monika Braun,Christoph Kahlert,Anna Spille,Christian Quack,Nuh N. Rahbari,Moritz Koch,Jürgen Weitz,Matthias Kloor,Inka Zoernig,Peter Schirmacher,Karsten Brand,Niels Grabe,Christine S. Falk +13 more
TL;DR: These findings indicate a distinct regulation of NK cells versus T cells in the CRC tumor microenvironment, which is obviously impaired early during tumor development by mechanisms that do not affect T-cell infiltration.