M
Martin Schmitt
Researcher at University of Freiburg
Publications - 32
Citations - 534
Martin Schmitt is an academic researcher from University of Freiburg. The author has contributed to research in topics: Acoustic wave & Lamb waves. The author has an hindex of 11, co-authored 32 publications receiving 474 citations. Previous affiliations of Martin Schmitt include Coburg University of Applied Sciences.
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Journal ArticleDOI
The role of histone demethylases in cancer therapy
Inga Hoffmann,Martin Roatsch,Martin Schmitt,Luca Carlino,Martin Pippel,Wolfgang Sippl,Manfred Jung +6 more
TL;DR: This work reviews histone demethylases with a special focus on their potential role in oncology drug discovery, presenting an overview over the different classes of enzymes, their biochemistry, selected data on their role in physiology and already available inhibitors.
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Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity.
Martin Schmitt,Alexander-Thomas Hauser,Luca Carlino,Martin Pippel,Johannes Schulz-Fincke,Eric Metzger,Dominica Willmann,Teresa T. Yiu,Teresa T. Yiu,Michelle Craig Barton,Roland Schüle,Wolfgang Sippl,Manfred Jung +12 more
TL;DR: On the basis of these substrate mimicking inhibitors, a combination of similarity-based virtual screening and subsequent synthetic optimization resulting in more druglike LSD1 inhibitors that led to histone hypermethylation in breast cancer cells is reported.
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Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing.
Urszula Uciechowska,Jörg Schemies,Robert C. Neugebauer,Elisabeth-Maria Huda,Martin Schmitt,Rene Meier,Eric Verdin,Manfred Jung,Wolfgang Sippl +8 more
TL;DR: The combination of docking and in vitro experimental testing resulted in the identification of novel sirtuin inhibitors with thiobarbiturate structure and the identified compounds will be used to further explore the therapeutic potential of sirtuins.
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Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.
Benjamin Maurer,Tobias Rumpf,Michael Scharfe,Diana A. Stolfa,Martin Schmitt,Wenjuan He,Eric Verdin,Wolfgang Sippl,Manfred Jung +8 more
TL;DR: Thiobarbiturates were identified as new Sirt5 inhibitors in the low micromolar range, which are selective over Sirt3 that can be found in the same cell compartment as Sirt 5.
Journal ArticleDOI
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML.
Jessica Barth,Jessica Barth,Khalil Abou-El-Ardat,Khalil Abou-El-Ardat,Denis Dalic,Nina Kurrle,Anna-Maria Maier,Sebastian Mohr,Judith Schütte,Lothar Vassen,Gabriele Greve,Gabriele Greve,Johannes Schulz-Fincke,Johannes Schulz-Fincke,Martin Schmitt,Milica Tosic,Eric Metzger,Gesine Bug,Gesine Bug,Cyrus Khandanpour,Sebastian Wagner,Sebastian Wagner,Michael Lübbert,Michael Lübbert,Manfred Jung,Manfred Jung,Hubert Serve,Hubert Serve,Roland Schüle,Tobias Berg,Tobias Berg +30 more
TL;DR: It is believed that targeting both enzymatic and scaffolding functions of LSD1 is required to efficiently treat AML, and the identified biomarkers may be relevant for the treatment of AML patients with LSD1 inhibitors.