M
Martti Marvola
Researcher at University of Helsinki
Publications - 91
Citations - 2080
Martti Marvola is an academic researcher from University of Helsinki. The author has contributed to research in topics: Dosage form & Bioavailability. The author has an hindex of 26, co-authored 91 publications receiving 2010 citations.
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Journal ArticleDOI
Enteric polymers as binders and coating materials in multiple-unit site-specific drug delivery systems
TL;DR: The main conclusion was that drug release can be targeted on the distal part of the small intestine and the colon by preparing film-coated matrix pellets in which enteric polymers dissolving at pH approximately 7 have been used both as binders in the pellets and as coating material.
Journal ArticleDOI
Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery.
Karin Krogars,Jyrki Heinämäki,Johanna Vesalahti,Martti Marvola,Osmo Antikainen,Jouko Yliruusi +5 more
TL;DR: In small amounts Eudragit S increased pellet roundness but in larger amounts pelletroundness was reduced and the combination of citric acid and enteric coating delayed the drug release for 15 min in a pH 7.4 phosphate buffer.
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In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters.
TL;DR: The optimum pH for preparing a drug delivery device for dexmedetomidine, is near the zero charge of silica xerogel, where the degradation of the matrix was also slowest.
Journal ArticleDOI
Alkyl-substituted silica gel as a carrier in the controlled release of dexmedetomidine.
Pirjo Kortesuo,Manja Ahola,Minna Kangas,Tiina Leino,Sirpa Laakso,Lauri Vuorilehto,Antti Yli-Urpo,Juha Kiesvaara,Martti Marvola +8 more
TL;DR: The effect of alkyl substitution of the silica xerogel matrix on the release rate of dexmedetomidine was evaluated and a burst in drug release was shown fromAlkyl-substituted silica gel microparticles.
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Citric acid as excipient in multiple-unit enteric-coated tablets for targeting drugs on the colon.
TL;DR: Citric acid retarded in vitro drug release when used in multiple-unit tablets and in vivo absorption of ibuprofen was markedly delayed when citric acid was included in both granules and tablet matrix.