M
Mary Aakre
Researcher at Vanderbilt University
Publications - 29
Citations - 5141
Mary Aakre is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Transforming growth factor beta & Transforming growth factor. The author has an hindex of 25, co-authored 29 publications receiving 4866 citations. Previous affiliations of Mary Aakre include Vanderbilt University Medical Center.
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Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer
Brian Bierie,Christine H. Chung,Joel S. Parker,Daniel G. Stover,Nikki Cheng,Anna Chytil,Mary Aakre,Yu Shyr,Harold L. Moses +8 more
TL;DR: Assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer.
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Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation
TL;DR: The data indicate that signaling from endogenous TGF-betas not only plays an important role in normal mammary gland physiology but also can also suppress the early stage of tumor formation and contribute to tumor invasion once carcinomas have developed.
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Transforming Growth Factor–β Regulates Mammary Carcinoma Cell Survival and Interaction with the Adjacent Microenvironment
Brian Bierie,Daniel G. Stover,Ty W. Abel,Anna Chytil,Agnieszka E. Gorska,Mary Aakre,Elizabeth Forrester,Li Yang,Kay Uwe Wagner,Harold L. Moses +9 more
TL;DR: The current results indicate that loss of TGF-beta signaling in mammary alveolar progenitors may affect tumor initiation, progression, and metastasis through regulation of both intrinsic cell signaling and adjacent stromal-epithelial interactions in vivo.
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TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest.
TL;DR: Evidence is presented that signaling through RhoA and p160ROCK is important in TGF-β inhibition of cell proliferation and links signaling components for epithelial transdifferentiation with regulation of cell-cycle progression.
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TGF-β Receptor II Loss Promotes Mammary Carcinoma Progression by Th17 Dependent Mechanisms
Sergey V. Novitskiy,Michael W. Pickup,Agnieszka E. Gorska,Philip Owens,Anna Chytil,Mary Aakre,Huiyun Wu,Yu Shyr,Harold L. Moses +8 more
TL;DR: Analysis of human breast cancer transcriptome databases showed a strong association between IL-17 gene expression and poor outcome in lymph node positive, estrogen receptor negative or luminal B subtypes suggesting potential therapeutic approaches.