M
Mary Aakre
Researcher at Vanderbilt University
Publications - 29
Citations - 5141
Mary Aakre is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Transforming growth factor beta & Transforming growth factor. The author has an hindex of 25, co-authored 29 publications receiving 4866 citations. Previous affiliations of Mary Aakre include Vanderbilt University Medical Center.
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Inhibition of cell growth by TGF beta 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and Mv1Lu cells.
TL;DR: Evidence is cited suggesting that the inhibition of B-myb and cyclin A may contribute to the late G1 arrest caused by TGF beta 1 and that these events may be linked through the actions of the product of the retinoblastoma susceptibility gene (Rb) or an Rb family member.
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Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes
Anna Chytil,Mary Waltner-Law,Robert W. West,David B. Friedman,Mary Aakre,Dana Barker,Brian K. Law +6 more
TL;DR: It is demonstrated that Cdk2 in cyclin D1-Cdk2 complexes from mammary epithelial cells is phosphorylated on the activating phosphorylation site, Thr160, and that the cyclIn D1 domain of the fusion protein activated the Cdk1 domain through an intramolecular mechanism.
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GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma.
Ty W. Abel,Cara Clark,Brian Bierie,Anna Chytil,Mary Aakre,Agnieszka E. Gorska,Harold L. Moses +6 more
TL;DR: Data in animal models suggest that infiltrating tumor cells may arise from NSC transformed by activation of oncogenic K-ras in vivo, and that tumors are initiated in the subventricular zone (SVZ), a stem/progenitor cell niche in the mature brain.
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Quantitative analysis of the secretome of TGF‐β signaling‐deficient mammary fibroblasts
Baogang J. Xu,Wenwei Yan,Bojana Jovanovic,Angel Q. An,Nikki Cheng,Mary Aakre,Yajun Yi,Jimmy K. Eng,Andrew J. Link,Harold L. Moses +9 more
TL;DR: Hundreds of specific extracellular protein changes modulated by deletion of TβRII in mammary fibroblasts are revealed, which may play important roles in the tumor microenvironment.
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Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis
Sergey V. Novitskiy,Elizabeth Forrester,Michael W. Pickup,Agnieszka E. Gorska,Anna Chytil,Mary Aakre,Dina Polosukhina,Philip Owens,Dilyara R Yusupova,Zhiguo Zhao,Fei Ye,Yu Shyr,Harold L. Moses +12 more
TL;DR: Insight is provided into a novel mechanism by which epithelial TGFβ signaling modulates the tumor microenvironment, and by which it is involved in lung metastasis in HER2+ breast cancer patients.