M
Mary E.D. Flowers
Researcher at Fred Hutchinson Cancer Research Center
Publications - 250
Citations - 24148
Mary E.D. Flowers is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Transplantation & Hematopoietic stem cell transplantation. The author has an hindex of 66, co-authored 233 publications receiving 20832 citations. Previous affiliations of Mary E.D. Flowers include University of Washington & University of Washington Medical Center.
Papers
More filters
Journal ArticleDOI
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. Diagnosis and Staging Working Group Report
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more
TL;DR: The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence, and focuses attention on the causes of organ-specific abnormalities to chronic GVHD.
Journal ArticleDOI
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
Madan Jagasia,Hildegard T. Greinix,Mukta Arora,Kirsten M. Williams,Daniel Wolff,Edward W. Cowen,Jeanne Palmer,Daniel J. Weisdorf,Nathaniel S. Treister,Guang-Shing Cheng,Holly Kerr,Pamela Stratton,Rafael F. Duarte,George B. McDonald,Yoshihiro Inamoto,Afonso Celso Vigorito,Sally Arai,Manuel B. Datiles,David A. Jacobsohn,Theo Heller,Carrie L. Kitko,Sandra A. Mitchell,Paul J. Martin,Howard M. Shulman,Roy S. Wu,Corey Cutler,Georgia B. Vogelsang,Stephanie J. Lee,Steven Z. Pavletic,Mary E.D. Flowers +29 more
TL;DR: In this article, the authors proposed a new clinical scoring system (0-3) that describes the extent and severity of chronic graft-versus-host disease for each organ or site at any given time, taking functional impact into account.
Journal ArticleDOI
Chronic graft-versus-host disease.
TL;DR: Chronic graft versus host disease (GvHD) continues to be a significant problem in the allogeneic stem cell transplant setting and, as the authors continue to use alternative stem cell sources and attempt to modulate the immune system to increase an anti-tumour effect, they will probably see rising numbers of patients with this complication.
Journal ArticleDOI
Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity.
Michael Boeckh,Wendy M. Leisenring,Stanley R. Riddell,Raleigh A. Bowden,Meei Li Huang,David Myerson,Terry Stevens-Ayers,Mary E.D. Flowers,Terri Cunningham,Lawrence Corey +9 more
TL;DR: CMV viral load, lymphopenia, and CMV-specific T-cell immunodeficiency are predictors of late CMV disease and death after allogeneic stem cell transplantation, and prevention strategies should be targeted at patients in whom CMV reactivated during the first 3 months and those with poor CMv-specific immunity or low CD4 counts.
Journal ArticleDOI
Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation.
Marco Mielcarek,Paul J. Martin,Wendy M. Leisenring,Mary E.D. Flowers,David G. Maloney,Brenda M. Sandmaier,Michael B. Maris,Rainer Storb +7 more
TL;DR: The results show that nonablative HSCT is associated with a syndrome of acute GVHD occurring after day 100 in many patients, and should be taken into consideration in the design of prospective studies comparing GV HD resulting from the two types of transplantation procedures.